Guangdong P.D.Pharmaceutical Co., Ltd.

This product has a broad-spectrum antimicrobial effect in vitro, including aerobic Gram-negative and Gram-positive bacteria, anaerobes, Rickettsia, spirochetes and Chlamydia. It has bactericidal effects on the following bacteria: Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis. It only has antibacterial effects on the following bacteria: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, Group B hemolytic Streptococcus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, Salmonella paratyphi, Shigella, Bacteroides fragilis and other anaerobic bacteria. The following bacteria are usually resistant to chloramphenicol: Pseudomonas aeruginosa, Acinetobacter, Enterobacter, Serratia marcescens, indole-positive Proteus, methicillin-resistant Staphylococcus and Enterococcus. This product is an antibacterial agent. Chloramphenicol is fat-soluble and enters bacterial cells by diffusion, and reversibly binds to the 50S subunit of the bacterial ribosome, which blocks the growth of the peptide chain (possibly due to the inhibition of the action of transpeptidase), thereby inhibiting the formation of the peptide chain and preventing protein synthesis.

This product is a benzimidazole derivative, which is rapidly metabolized into sulfoxide, sulfone alcohol and 2-amine sulfone alcohol in the body. It selectively and irreversibly inhibits the polymerization of the cytoplasmic microtubule system of the parasite's intestinal wall cells, blocks its absorption of various nutrients and glucose, leads to the depletion of endogenous glycogen in the worm, and inhibits the fumarate reductase system, preventing the production of adenosine triphosphate, making it impossible for the worm to survive and reproduce. Similar to mebendazole, this product can also cause the degeneration of the cytoplasmic microtubules of the worm's intestinal cells, and bind to its microtubule protein, causing intracellular transport blockage, resulting in the accumulation of Golgi endocrine granules, the gradual dissolution of the cytoplasm, and the complete degeneration of the absorbing cells, causing the death of the worm. This product has the effect of completely killing hookworm eggs and whipworm eggs and partially killing ascarid eggs. In addition to killing and expelling various nematodes parasitic in animals, it also has a significant killing and expelling effect on tapeworms and cysticerci.

The second generation cephalosporin is an oral semi-synthetic antibiotic with a broad-spectrum antibacterial effect. It achieves bactericidal effect by inhibiting the synthesis of cell wall. It is stable to the β-lactamase of some bacteria and has antibacterial activity against most of the following microorganisms: Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae) and Gram-negative bacteria (Haemophilus influenzae, Moraxella catarrhalis).

This product belongs to the azole antifungal drug with a wide antifungal spectrum. It inhibits the biosynthesis of ergosterol on the fungal cell membrane by highly selectively interfering with the activity of fungal cytochrome P-450. It is effective against Candida infection, Cryptococcus neoformans infection, Malassezia furfur and other fungal infections. The antibacterial activity in vivo is significantly higher than that in vitro.

Strengthen the function of the brainstem reticular formation, especially the ascending reticular formation excitatory system which is closely related to consciousness; strengthen the function of the vertebral system and improve motor paralysis; improve cerebral circulation, promote brain metabolism by reducing cerebral blood flow resistance and increasing cerebral blood flow, and play a certain role in promoting brain function recovery and awakening.