(-)-Chloramphenicol

The main ingredient of this product is chloramphenicol, and its chemical name is D-threo-(-)-N-[α-(hydroxymethyl)-β-hydroxy-p-nitrophenylethyl]-2,2-dichloroacetamide.

1. Antiepileptic drugs (hydantoins). Chloramphenicol can inhibit the activity of liver cell microsomal enzymes, resulting in reduced metabolism of such drugs, or chloramphenicol can replace the serum protein binding sites of such drugs, which can enhance the effect of the drugs or increase their toxicity. Therefore, when used with chloramphenicol or after it, the dosage of such drugs must be adjusted. 2. When used with hypoglycemic drugs (such as tolbutamide), the hypoglycemic effect can be enhanced due to the replacement of protein binding sites, so the dosage of such drugs needs to be adjusted. The non-ionic binding characteristics of glipizide and glyburide make them less affected than other hypoglycemic drugs, but caution is still required when used together. 3. Long-term use of contraceptives containing estrogen, such as chloramphenicol, can reduce the reliability of contraception and increase menstrual bleeding. 4. Since this product can have the effect of vitamin B6 antagonists or increase the renal excretion of the latter, it can lead to anemia or peripheral neuritis. Therefore, when vitamin B6 is used together with this product, the body's need for the former increases. 5 This product can antagonize the hematopoietic effect of vitamin B12, so the two should not be used together. 6 When used with certain bone marrow suppressive drugs, it can enhance the bone marrow suppressive effect, such as anti-tumor drugs, colchicine, hydroxyphenylbutazone, phenylbutazone and penicillamine. When radiotherapy is performed at the same time, the bone marrow suppressive effect can also be enhanced, and the dose of bone marrow suppressants or radiotherapy must be adjusted. 7 If used before or during surgery, due to the inhibitory effect of this product on liver enzymes, it can reduce the clearance of the induced anesthetic alfentanil and prolong its duration of action. 8 When liver enzyme inducers such as phenobarbital and rifampicin are used with this product, their metabolism can be enhanced, resulting in a decrease in blood drug concentrations. 9 Antagonistic effects may occur when used in combination with macrolide antibiotics such as lincomycin or erythromycin, so it is not suitable for combined use.

The main ingredient of this product is chloramphenicol, and its chemical name is D-threo-(-)-N-[α-(hydroxymethyl)-β-hydroxy-p-nitrophenylethyl]-2,2-dichloroacetamide.

Combination use with macrolide antibiotics such as lincomycin or erythromycin may cause antagonism, so it is not suitable for combined use.

The main ingredient of this product is chloramphenicol, and its chemical name is D-threo-(-)-N-[α-(hydroxymethyl)-β-hydroxy-p-nitrophenylethyl]-2,2-dichloroacetamide.

1. Antiepileptic drugs (hydantoins). Chloramphenicol can inhibit the activity of liver cell microsomal enzymes, resulting in reduced metabolism of such drugs, or chloramphenicol can replace the serum protein binding sites of such drugs, which can enhance the effect of the drugs or increase their toxicity. Therefore, when used with chloramphenicol or after it, the dosage of such drugs must be adjusted. 2. When used with hypoglycemic drugs (such as tolbutamide), the hypoglycemic effect can be enhanced due to the replacement of protein binding sites, so the dosage of such drugs needs to be adjusted. The non-ionic binding characteristics of glipizide and glyburide make them less affected than other hypoglycemic drugs, but caution is still required when used together. 3. Long-term use of contraceptives containing estrogen, such as chloramphenicol, can reduce the reliability of contraception and increase menstrual bleeding. 4. Since this product can have the effect of vitamin B6 antagonists or increase the renal excretion of the latter, it can lead to anemia or peripheral neuritis. Therefore, when vitamin B6 is used together with this product, the body's need for the former increases. 5 This product can antagonize the hematopoietic effect of vitamin B12, so the two should not be used together. 6 When used with certain bone marrow suppressive drugs, it can enhance the bone marrow suppressive effect, such as anti-tumor drugs, colchicine, hydroxyphenylbutazone, phenylbutazone and penicillamine. When radiotherapy is performed at the same time, the bone marrow suppressive effect can also be enhanced, and the dose of bone marrow suppressants or radiotherapy must be adjusted. 7 If used before or during surgery, due to the inhibitory effect of this product on liver enzymes, it can reduce the clearance of the induced anesthetic alfentanil and prolong its duration of action. 8 When liver enzyme inducers such as phenobarbital and rifampicin are used with this product, their metabolism can be enhanced, resulting in a decrease in blood drug concentrations. 9 Antagonistic effects may occur when used in combination with macrolide antibiotics such as lincomycin or erythromycin, so it is not suitable for combined use.