Lomeza is a broad-spectrum quinolone antibiotic that has bactericidal effects on Gram-negative bacteria, Gram-positive bacteria and some anaerobic bacteria. It has good antibacterial effects on methicillin-resistant Staphylococcus aureus, ampicillin-resistant influenza bacilli, pipemidic acid-resistant Escherichia coli and bacteria resistant to other drugs. Its antibacterial mechanism is to inhibit the activity of bacterial DNA helicase, thereby inhibiting bacterial DNA transcription and replication, and has bactericidal effects on a variety of Gram-positive and Gram-negative bacteria.

1. Effect on water and electrolyte excretion: It can increase the excretion of water, sodium, chloride, potassium, calcium, magnesium, phosphorus, etc.; mainly by inhibiting the active reabsorption of NaCl by the thick wall segment of the renal tubular loop, reducing the osmotic pressure gradient difference of the medullary interstitial fluid, reducing the reabsorption of water, Na+, and Cl-, promoting the excretion of K+ and H+, and increasing the excretion of Ca2+ and Mg2+. Short-term medication can increase uric acid excretion, and long-term medication can cause hyperuricemia. 2. Effect on hemodynamics: Inhibit prostaglandin degrading enzyme activity, increase prostaglandin E2 content, dilate blood vessels; reduce renal vascular resistance, increase renal blood flow; dilate pulmonary capacitance veins, reduce pulmonary capillary permeability, reduce ventricle return blood volume, reduce left ventricular end-diastolic pressure, and help treat acute left heart failure and adult respiratory distress syndrome.

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