Topfond Pharmaceutical Co., Ltd.

This product is a coenzyme. Adenosine triphosphate disodium is a nucleotide derivative that participates in the metabolism of fat, protein, sugar, nucleic acid and nucleotide in the body. When energy is needed for absorption, secretion, muscle contraction and biochemical synthesis reactions in the body, adenosine triphosphate is decomposed into adenosine diphosphate and phosphate groups, and energy is released at the same time. Adenosine triphosphate disodium can penetrate the blood-cerebrospinal fluid barrier, improve the stability and reconstruction ability of the membrane structure of nerve cells, and promote the regrowth of neurites.

It can relax the sphincter of Oddi, has strong antispasmodic and analgesic effects, and can also gently and continuously promote bile secretion, strengthen gallbladder contraction and antibacterial effects, has obvious choleretic effects, is conducive to the discharge of stones, and has a certain stone discharge effect on common bile duct stones. Some patients with elevated alanine aminotransferase will return to normal after taking the medicine as the inflammation is eliminated. This product has low toxicity, and the acute toxicity LD50 of mice is 5375mg/kg.

This product is a piperazine calcium channel antagonist that can block calcium influx into vascular smooth muscle, causing vasodilation and improving cerebral and coronary circulation, especially having a certain selective effect on cerebral blood vessels. This product can inhibit phosphodiesterase, prevent cAMP from decomposing into inactive 5-AMP, thereby increasing the intracellular cAMP concentration, inhibiting the release of histamine, 5-hydroxytryptamine, bradykinin and other biologically active substances, and also inhibiting the activation of complement C4.

It has a good antibacterial effect on human tuberculosis bacteria, and its bactericidal effect is strongest at pH 5-5.5. It is currently the best bactericidal drug for tuberculosis bacteria that grow slowly in phagocytes in an acidic environment. The antibacterial concentration in vivo is 12.5μg/ml, and 50μg/ml can kill tuberculosis bacteria. The concentration that inhibits tuberculosis bacteria inside cells is 10 times lower than that outside cells, and it has almost no antibacterial effect in neutral and alkaline environments. The mechanism of action may be related to pyrazinoic acid. After pyrazinamide penetrates into phagocytes and enters the tuberculosis bacteria, the amidase in the bacteria removes the amide group and converts it into pyrazinoic acid to exert an antibacterial effect. In addition, because pyrazinamide is similar to nicotinamide in chemical structure, it interferes with dehydrogenase by replacing nicotinamide, prevents dehydrogenation, and hinders the use of oxygen by tuberculosis bacteria, which affects the normal metabolism of bacteria and causes death.

It has a good antibacterial effect on human tuberculosis bacteria, and its bactericidal effect is strongest at pH 5-5.5. It is currently the best bactericidal drug for tuberculosis bacteria that grow slowly in phagocytes in an acidic environment. The antibacterial concentration in vivo is 12.5μg/ml, and 50μg/ml can kill tuberculosis bacteria. The concentration that inhibits tuberculosis bacteria inside cells is 10 times lower than that outside cells, and it has almost no antibacterial effect in neutral and alkaline environments. The mechanism of action may be related to pyrazinoic acid, which interferes with dehydrogenase by replacing nicotinamide, preventing dehydrogenation, hindering the use of oxygen by tuberculosis bacteria, affecting the normal metabolism of bacteria and leading to death.