Almost all of it is converted into 6-mercaptopurine in the body to work. Because of its slow conversion process, it works slowly. It can inhibit Friend leukemia, inhibit virus infection in mice, inhibit spleen enlargement, and reduce the virus titer in the spleen and plasma. Rats injected with this product intraperitoneally for 4 to 5 months have weight loss, severe anemia and increased reticulocytes. Rabbits given this drug in early pregnancy can cause teratogenesis, mainly affecting limb development. It can have an immunosuppressive effect by interfering with RNA metabolism. If a small dose exists in the culture medium for a long time, it can inhibit the killing cell effect of sensitized lymphocytes in vitro.

Finasteride is a synthetic steroidal compound that is a specific inhibitor of the intracellular enzyme type II 5alpha;-reductase in the metabolism of the androgen testosterone to dihydrotestosterone. Finasteride has no affinity for androgen receptors and has no androgenic, anti-androgenic, estrogenic, anti-estrogenic or progestational effects. Inhibition of this enzyme can hinder the conversion of testosterone to the androgen dihydrotestosterone in peripheral tissues, resulting in a significant decrease in the concentration of dihydrotestosterone in serum and tissues. Compared with placebo, it can increase the level of testosterone in the blood circulation by about 10-15%, but it is still within the physiological range. Finasteride can rapidly reduce the concentration of dihydrotestosterone in serum, and significantly reduce it within 24 hours after administration. Hair follicles contain type II 5alpha;-reductase. In the bald areas of patients with male pattern baldness, the hair follicles in the scalp become smaller and dihydrotestosterone increases. Administration of finasteride can reduce the concentration of dihydrotestosterone in the scalp and serum of these patients. Men who are congenitally deficient in type II 5alpha;-reductase will not suffer from male pattern baldness. These data and the results of clinical studies confirm that finasteride can inhibit the shrinkage of scalp hair follicles and reverse the process of hair loss.

This drug belongs to the 4-nitrogen steroid hormone compound and is a specific type II 5alpha;-reductase competitive inhibitor. It inhibits the conversion of peripheral testosterone into dihydrotestosterone and reduces the levels of dihydrotestosterone in the blood, prostate, skin and other tissues. The growth, development and benign hyperplasia of the prostate depend on dihydrotestosterone. Finasteride inhibits prostate hyperplasia by reducing the levels of dihydrotestosterone in the blood and prostate tissues, and improves the related clinical symptoms of benign prostatic hyperplasia.

Inhibit platelet aggregation and prevent thrombosis; counteract vascular damage caused by serotonin and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability.

Extract from the above information