Shijiazhuang No.4 Pharmaceutical Co., Ltd.

Glycerol fructose injection is a hyperosmotic preparation that can reduce brain water content and intracranial pressure through hyperosmotic dehydration. This product has a slow onset and a longer duration of action in reducing intracranial pressure.

It has high activity against protozoa and anaerobic bacteria. It has antibacterial activity against Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium, Peptococcus, Peptostreptococcus, Veillonella and Gardnerella; microaerophilic bacteria and Helicobacter pylori are sensitive to it; the MIC against Trichomonas vaginalis is similar to that of metronidazole, and its metabolites are more active against Gardnerella than metronidazole. The mechanism of action of this product has not been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro group of this product is reduced to a cytotoxin, which acts on the DNA metabolism process of bacteria and promotes the death of bacteria. Resistant bacteria often lack nitroreductase and are resistant to this product. The mechanism of this product against amoeba is to inhibit its redox reaction, break the nitrogen chain of the protozoa, and thus kill the protozoa.

This product has a broad-spectrum antibacterial effect, especially against aerobic Gram-negative bacteria. It has high antibacterial activity against most bacteria of the Enterobacteriaceae family, penicillin-resistant Neisseria gonorrhoeae, enzyme-producing influenza bacilli and Moraxella, Pseudomonas aeruginosa, etc. It has antibacterial activity against methicillin-sensitive Staphylococcus aureus, and only moderate antibacterial activity against Streptococcus pneumoniae, hemolytic Streptococcus and Enterococcus faecalis. It has good antimicrobial effects on Chlamydia trachomatis, Mycoplasma, and Legionella, and also has antibacterial activity against Mycobacterium tuberculosis and atypical mycobacteria. It has poor antibacterial activity against anaerobic bacteria. Ciprofloxacin is a bactericide that acts on the A subunit of bacterial DNA helicase, inhibits DNA synthesis and replication, and causes bacterial death.