Jiangsu Nhwa Pharmaceutical Co., Ltd.

It selectively inhibits succinate dehydrogenase in the muscles of the worm, affects the anaerobic metabolism of the worm muscles, and reduces energy production; it depolarizes the nerve muscles, causing continuous muscle contraction and paralysis; its cholinergic effect is beneficial to the excretion of the worm; it may have an inhibitory effect on the microtubule structure of the worm; it has immune regulation and immune preparation functions.

This product and its metabolites are cyclic adenosine monophosphate (cAMP) phosphodiesterase III inhibitors (PDEIII inhibitors), which can reduce the degradation of cAMP by inhibiting the activity of phosphodiesterase, thereby increasing the cAMP level in platelets and blood vessels, inhibiting platelet aggregation and vasodilation.

Fluconazole is a new triazole antifungal drug with a broad-spectrum antifungal effect and can selectively inhibit fungal sterol synthesis. It is effective against Candida infections, Cryptococcus neoformans infections, Malassezia sacchari, Microsporum, Trichophyton, Epidermophyton, Blastomyces dermatitidis, Coccidioides immitis, Histoplasma capsulatum, Peyer's Chromatids, and Cladosporium carinii. It has a highly selective inhibitory effect on fungal cytochrome p-450-dependent enzymes. Studies have shown that taking fluconazole has no effect on male plasma testosterone concentrations or plasma steroid concentrations in women of childbearing age; it has no significant effect on endogenous steroid levels or adrenocorticotropic hormone effects in healthy male volunteers.

It may block the generation and conduction of nerve impulses by increasing the threshold of nerve action potential, delaying the spread of nerve impulses, and reducing the speed of action potential increase. The generation of anesthetic effect is related to the axial diameter, myelination and conduction velocity of nerve fibers.