This product is a cell cycle-specific anti-tumor drug that acts on DNA topoisomerase II to form a stable reversible complex of drug-enzyme-DNA, which hinders DNA repair. Experiments have found that this complex can be reversed with the elimination of the drug, allowing the damaged DNA to be repaired and reducing cytotoxicity. Therefore, extending the drug administration time may increase the anti-tumor activity.

Warming and tonifying kidney yang

Warming and tonifying kidney yang

Warming and tonifying kidney yang

Warming and tonifying kidney yang

Warming and tonifying kidney yang

Warming and tonifying kidney yang

Warming and tonifying kidney yang

Warming and tonifying kidney yang

This product belongs to the macrolide antibiotics, which is the ethyl succinate of erythromycin. It is more stable than erythromycin in gastric acid. It has antibacterial activity against Staphylococcus (except methicillin-resistant strains), various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. are also sensitive to this product. This product also has antibacterial effects on various anaerobic bacteria except Bacteroides fragilis and Fusobacterium. It also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can penetrate the bacterial cell membrane and form a reversible bond with the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) from binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis.

It acts on dihydrofolate synthase, interfering with the first step of folic acid synthesis; it has a synergistic antibacterial effect when used in combination with trimethoprim, which can double-block the bacterial folic acid metabolism.

It acts on the second step of folic acid anabolism and selectively inhibits the action of dihydrofolate reductase. It has a synergistic antibacterial effect when used in combination with sulfadiazine, which can double-block the bacterial folic acid metabolism.