Vitamin B6 is converted into pyridoxal phosphate in red blood cells and acts as a coenzyme in various metabolic functions of proteins, carbohydrates, and lipids. It is also involved in the conversion of tryptophan into niacin or 5-hydroxytryptamine.

Vitamin B6 is converted into pyridoxal phosphate in red blood cells and acts as a coenzyme in various metabolic functions of proteins, carbohydrates, and lipids. It is also involved in the conversion of tryptophan into niacin or 5-hydroxytryptamine.

Trimethoprim (TMP) is an antibacterial agent, a lipophilic weak base, and its chemical structure belongs to the pyrimethamine class. It has antibacterial activity against Escherichia coli, Klebsiella, Proteus mirabilis, Salmonella, and Shigella, but has no obvious antibacterial effect on Streptococcus pneumoniae, Neisseria gonorrhoeae, and Neisseria meningitidis, and has no effect on Pseudomonas aeruginosa. The mechanism of action of this product is to interfere with bacterial folic acid metabolism. It mainly selectively inhibits the activity of bacterial dihydrofolate reductase, so that dihydrofolate cannot be reduced to tetrahydrofolate, and synthetic folic acid is the main component of nucleic acid biosynthesis. Therefore, this product prevents the synthesis of bacterial nucleic acids and proteins, and the binding of this product to bacterial dihydrofolate reductase is 50,000 to 60,000 times tighter than that to mammalian enzymes. The combination of this product and sulfonamides can double block the bacterial folic acid synthesis metabolism, have a synergistic effect, enhance the antibacterial activity of sulfonamides, and convert the antibacterial effect into a bactericidal effect, reducing the production of drug-resistant strains.

This product has a broad-spectrum antimicrobial effect in vitro, including aerobic Gram-negative and Gram-positive bacteria, anaerobes, Rickettsia, spirochetes and Chlamydia. It has bactericidal effects on the following bacteria: influenza bacillus, Streptococcus pneumoniae and Neisseria meningitidis. It only has antibacterial effects on the following bacteria: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, group B hemolytic Streptococcus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, Salmonella paratyphi, Shigella, Bacteroides fragilis and other anaerobic bacteria. The following bacteria are usually resistant to chloramphenicol: Pseudomonas aeruginosa, Acinetobacter, Enterobacter, Serratia marcescens, indole-positive Proteus, methicillin-resistant Staphylococcus and Enterococcus. This product is an antibacterial agent. Chloramphenicol is fat-soluble and enters bacterial cells by diffusion, and reversibly binds to the 50S subunit of the bacterial ribosome, which blocks the growth of the peptide chain (possibly due to the inhibition of the action of transpeptidase), thereby inhibiting the formation of peptide chains and preventing protein synthesis.

It is a vasodilator that can dilate coronary arteries and cerebral blood vessels, reduce myocardial oxygen consumption, improve microcirculation and resist platelet aggregation. Animal experiments have shown that: 1. The various total flavonoid compounds in Pueraria root can relax smooth muscles, while the contractile components may be substances such as choline, acetylcholine and carbazine R; 2. Pueraria root has a certain antihypertensive effect on normal and hypertensive animals; 3. Pueraria root total flavonoids and puerarin have a significant dilating effect on coronary arteries, which can dilate normal and spasmodic coronary arteries. After intravenous injection, coronary blood flow can increase by 40% and vascular resistance can be reduced by 29%; 4. Puerarin can also inhibit the release of 5-HT in platelets induced by thrombin.