Xi'an Keli Pharmaceutical Co., Ltd.

Trimethoprim (TMP) is an antibacterial agent, a lipophilic weak base, and its chemical structure belongs to the pyrimethamine class. It has antibacterial activity against Escherichia coli, Klebsiella, Proteus mirabilis, Salmonella, and Shigella, but has no obvious antibacterial effect on Streptococcus pneumoniae, Neisseria gonorrhoeae, and Neisseria meningitidis, and has no effect on Pseudomonas aeruginosa. The mechanism of action of this product is to interfere with bacterial folic acid metabolism. It mainly selectively inhibits the activity of bacterial dihydrofolate reductase, so that dihydrofolate cannot be reduced to tetrahydrofolate, and synthetic folic acid is the main component of nucleic acid biosynthesis. Therefore, this product prevents the synthesis of bacterial nucleic acids and proteins, and the binding of this product to bacterial dihydrofolate reductase is 50,000 to 60,000 times tighter than that to mammalian enzymes. The combination of this product and sulfonamides can double block the bacterial folic acid synthesis metabolism, have a synergistic effect, enhance the antibacterial activity of sulfonamides, and convert the antibacterial effect into a bactericidal effect, reducing the production of drug-resistant strains.

This product is a neutral compound of aspirin and acetaminophen bonded by an ester bond. It has antipyretic and analgesic effects, with fewer adverse reactions than aspirin, and is easily tolerated by patients. After oral administration, it is not hydrolyzed in the gastrointestinal tract, is absorbed in the intestine and quickly reaches an effective concentration in the blood, and is characterized by rarely causing gastrointestinal bleeding.

This product is a neutral compound of aspirin and acetaminophen bonded by an ester bond. It has antipyretic and analgesic effects, with fewer adverse reactions than aspirin, and is easily tolerated by patients. After oral administration, it is not hydrolyzed in the gastrointestinal tract, is absorbed in the intestine and quickly reaches an effective concentration in the blood, and is characterized by rarely causing gastrointestinal bleeding.

It is a sulfonamide antibiotic that acts on dihydrofolate synthase. When used in combination with trimethoprim, it can double-block the bacterial folate metabolism and has a good antibacterial effect on a variety of bacteria.

It is a sulfonamide antibacterial synergist that acts on dihydrofolate reductase. When used in combination with sulfamethoxazole, it can enhance the antibacterial effect and reduce drug-resistant strains.