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Benorylate

Benorylate structure

CAS No:
5003-48-5
Formula:
C17H15NO5
Chemical Name:
Benorylate
Synonyms:
Benzoic acid,2-(acetyloxy)-,4-(acetylamino)phenyl ester;Salicylic acid acetate,ester with 4′-hydroxyacetanilide;Acetanilide,4′-hydroxy-,salicylate (ester) acetate (ester);p-Acetamidophenyl acetylsalicylate;4-Acetamidophenyl 2-acetoxybenzoate;4-Acetaminophenyl 2-acetoxybenzoate;Benorylate;Aspirin acetaminophen ester;Fenasprate;Benoral;Acetylsalicylic acid paracetamol ester;p-N-Acetylaminophenyl acetylsalicylate;Benorilate;Win 11450;TO 125;Benortan;Quinexin;Salipran
Categories:
Organic Chemistry > Amides

Description

Benorylate (Benoral) is the esterification product of paracetamol and acetylsalicylic acid. It has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis.

Benorilate is a carbonyl compound.

Benorylate Basic Attributes

Molecular Weight：

313.3

Exact Mass：

313.30

EC Number：

225-674-5

UNII：

W1QX9DV96G

DSSTox ID：

DTXSID5022649

ATC Code：

N - Nervous system

HScode：

2924299090

Characteristics

PSA：

81.7

XLogP3：

2.2

Density：

1.2±0.1 g/cm3

Melting Point：

175 °C

Boiling Point：

537.8°C at 760 mmHg

Flash Point：

263.1±32.9 °C

Refractive Index：

1.566

Water Solubility：

20mg/L(21 ºC)

Toxicity：

LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson)

Safety Information

RTECS Number：

VO0720000

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

2-acetoxy-4'-acetaminophenylbenzoate

Benorylate Use and Manufacturing

Methods of Manufacturing

Acetylsalicylic acid chloride is generated from acetylsalicylic acid through acid chlorination, and then condensed with p-acetamidophenol to obtain benoxate.

Uses

Benorilate is a codrug of Acetylsalicylic Acid (A187780) and Acetaminophen (A161220) and is used as an anti-inflammatory and antipyretic medication.

Computed Properties

Molecular Weight:313.30
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:313.09502258
Monoisotopic Mass:313.09502258
Topological Polar Surface Area:81.7
Heavy Atom Count:23
Complexity:442
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Aspirin

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Benoate
Manufacturer	Dandong Yichuang Pharmaceutical Co., Ltd.

Benornate Tablets
Ingredients	Benoate
Indication	1This product should not be used simultaneously with oral anticoagulants (such as warfarin and heparin). 2Drug interactions may occur if used simultaneously with other drugs. Please consult your doctor or pharmacist for details.
Specifications	0.2g
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Benoate Vitamin B1 Granules
Ingredients	This product is a compound preparation, each bag contains 0.3g of benolate and 3mg of vitamin B1. The auxiliary material is powdered sugar.
Indication	1. This product can prolong the prothrombin time when taken with oral anticoagulants. 2. If you are taking other medicines, please consult a physician or pharmacist before using this product.
Specifications	Benornate 0.5g, Vitamin B15mg
Manufacturer	Yaodu Pharmaceutical Co., Ltd.

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Registered Holders

Shaanxi Xiyue Pharmaceutical (Fufeng) Co., Ltd.

China
Active
Jiuquan Dadeli Pharmaceutical Co., Ltd.

China
Active
Guangxi LMZ Yikang Pharmaceutical Co., Ltd.

China
Active

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