This product is a compound of aminopyrine and sodium sulfite. It is easily soluble in water and has faster and stronger antipyretic and analgesic effects than aminopyrine.

This product is a compound of aminopyrine and sodium sulfite. It is easily soluble in water and has faster and stronger antipyretic and analgesic effects than aminopyrine.

Interfering with the first step of folic acid synthesis, combined with trimethoprim, can double block the folic acid metabolism of bacteria, enhance the synergistic antibacterial effect, and reduce drug-resistant strains. It has good antibacterial effects on non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, etc.

It selectively inhibits the action of dihydrofolate reductase. When used in combination with sulfamethoxazole, it can double block the bacterial folic acid metabolism, enhance the synergistic antibacterial effect, and reduce drug-resistant strains. It has good antibacterial effects on non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, etc.

It combines with adenosine triphosphate to form vitamin B1 pyrophosphate (thiamine diphosphate, cocarboxylase), which is a coenzyme necessary for carbohydrate metabolism; it can inhibit the activity of cholinesterase. When it is deficient, cholinesterase activity is enhanced, acetylcholine hydrolysis is accelerated, causing nerve impulse conduction disorders and affecting gastrointestinal and myocardial function.

This product is a broad-spectrum antibacterial agent with bactericidal effect at high concentrations. In addition to common Gram-positive bacteria, Gram-negative bacteria and anaerobic bacteria, most Rickettsia, Mycoplasma, Chlamydia, atypical mycobacteria and spirochetes are also sensitive to this product. This product is better than Gram-positive bacteria for Gram-negative bacteria, but Enterococcus is resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, etc. are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant gonococci are also resistant to tetracycline. This product has good antibacterial effect on Gram-negative bacteria such as Vibrio, Yersinia pestis, Brucella, Campylobacter, Yersinia, etc., has no antibacterial activity against Pseudomonas aeruginosa, and has certain antibacterial effect on some anaerobic bacteria, but it is far inferior to metronidazole, clindamycin and chloramphenicol, so it is not used clinically. Due to the widespread use of tetracyclines over the years, most common clinical pathogens, including Gram-positive bacteria such as Staphylococcus and Gram-negative bacteria such as Enterobacter, are resistant to tetracyclines, and there is cross-resistance between similar products. The mechanism of action of this product is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, preventing the binding of aminoacyl-tRNA at this position, thereby inhibiting the growth of the peptide chain and affecting the synthesis of bacterial proteins.