Concentrated Sodium Chloride Injection

The main ingredients of this product and its chemical name: Sodium chloride Chemical structure: NaCl Molecular formula: NaCl Molecular weight: 58.44

This product is a colorless, clear liquid with a salty taste.

Water intoxication and severe hyponatremia caused by various reasons. This product can quickly increase the osmotic pressure of the extracellular fluid, thereby moving the water in the intracellular fluid to the outside of the cell. While increasing the volume of the extracellular fluid, it can also increase the osmotic pressure of the intracellular fluid.

In case of severe hypotonic water loss, the solutes in brain cells decrease to maintain cell volume. If the treatment causes the plasma and extracellular fluid sodium concentration and osmotic concentration to rise rapidly, brain cell damage may occur. It is generally believed that when blood sodium is lower than 120mmol/L, the treatment causes the blood sodium to rise at a rate of 0.5mmol/L per hour and should not exceed 1.5mmol/L per hour. When blood sodium is lower than 120mmol/L or central nervous system symptoms appear, 3% to 5% sodium chloride injection can be given by slow drip. It is generally required to increase the blood sodium concentration to above 120mmol/L within 6 hours. Sodium supplementation amount (mmol) = [142-actual blood sodium concentration (mmol/L)] × body weight (kg) × 0.2. When blood sodium rises to above 120-125mmol/L, isotonic solution can be used instead or hypertonic glucose injection or 10% sodium chloride injection can be added to the isotonic solution as appropriate.

(1) Excessive and rapid infusion can cause water and sodium retention, resulting in edema, increased blood pressure, increased heart rate, chest tightness, and dyspnea. (2) Inappropriate administration of hypertonic sodium chloride can cause hypernatremia and even acute left heart failure.

It should be used with caution or prohibited in the following situations: ① Edema diseases, such as nephrotic syndrome, ascites due to liver cirrhosis, congestive heart failure, acute left heart failure, cerebral edema and idiopathic edema; ② Oliguria in acute renal failure and poor response to diuretics in chronic renal failure; ③ Hypertension and hypokalemia; ④ Hyperosmotic or isotonic water loss.

The experiment was not conducted and there is no reliable reference

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