Aminobenzoic acid injection
Function and Efficacy
This product is a procoagulant. There are various natural antagonists of plasmin (ogen) in the blood circulation, such as antiplasmin. Under normal circumstances, the activity of antifibrinolytic substances in the blood is many times higher than that of fibrinolytic substances, so fibrinolytic bleeding will not occur. However, these antagonists cannot block the activation of activators (such as urokinase, etc.) adsorbed on the fibrin network to form plasmin. Plasmin is a kind of endopeptidase that can cleave the arginine and lysine peptide chains of fibrin (ogen) in a neutral environment to form fibrin degradation products and cause blood clot dissolution and bleeding. Plasminogen specifically adsorbs on fibrin through the lysine binding site in its molecular structure, and lysine can competitively inhibit this adsorption, reduce the adsorption rate of plasminogen, and thus reduce the activation process of plasminogen.
Ingredients
The main ingredient and chemical name of this product are: p-aminomethylbenzoic acid-hydrate
Appearance
This product is a colorless clear liquid.
Indication
This product is mainly used for bleeding caused by excessive primary fibrinolysis, including acute and chronic, localized, or systemic hyperfibrinolytic bleeding. The latter is common in cancer, leukemia, gynecological accidents, severe liver disease bleeding, etc.
Usage and Dosage
Intravenous injection or drip: 0.1-0.3g each time, not more than 0.6g per day.
Adverse Reactions
Compared with 6-aminocaproic acid, this product has 5 times stronger antifibrinolytic activity. Adverse reactions are extremely rare. No thrombosis has been observed in long-term use, but dizziness, headache, and pupil discomfort may occur occasionally. Patients with a tendency to myocardial infarction should use it with caution.
Precautions
It is contraindicated for those who are allergic to this product.
Drug Interactions
(1) It is incompatible with thrombolytic agents such as penicillin or urokinase; (2) The combined use of oral contraceptives, estrogens or prothrombin complex concentrates with this product may increase the risk of thrombosis.
Storage
Keep sealed.
Packaging Specification
10ml:0.1g
Manufacturer
Shanghai Pujin Linzhou Pharmaceutical Co., Ltd.
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Founded in:
2005-04-12 -
Address:
West section of Xinglin Road, Linzhou City -
Tax NO.:
914105811724312882 -
Registered Funds:
25 million yuan -
Website:
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Email: