Isoniazid Vitamin B6 Tablets

This product is a synthetic antibacterial drug with bactericidal effect. It is only effective against mycobacteria, mainly bacteria in the growth and reproduction period. Its mechanism of action has not yet been elucidated, and it may inhibit the synthesis of mycolic acid in sensitive bacteria and cause cell wall rupture.

The main ingredient of this product is isoniazid, and its chemical name is 4-pyridinecarboxylic acid hydrazide.

This product is white tablets.

1. Isoniazid combined with other anti-tuberculosis drugs is suitable for the treatment of various types of tuberculosis, including tuberculous meningitis and other mycobacterial infections. 2. Isoniazid alone is suitable for the prevention of various types of tuberculosis: ① Family members or close contacts of patients recently diagnosed with tuberculosis; ② Those who have a strongly positive tuberculin purified protein derivative test (PPD) and a chest X-ray examination consistent with non-progressive tuberculosis, negative sputum bacteria, and have not received formal anti-tuberculosis treatment in the past; ③ Patients who are receiving immunosuppressants or long-term hormone therapy, certain blood diseases or reticuloendothelial system diseases (such as leukemia, Hodgkin's disease), diabetes, uremia, silicosis or gastrectomy, and whose tuberculin purified protein derivative test is positive; ④ Positive tuberculin purified protein derivative test under 35 years old

Oral prevention: 0.3g (3 tablets) per day for adults, taken at once; 10mg/kg per day for children, not exceeding 0.3g (3 tablets) per day, taken at once. Treatment: Adults take 5mg/kg per day orally, up to 0.3g (3 tablets) per day, or 15mg/kg per day, up to 900mg (9 tablets), 2 to 3 times a week, in combination with other anti-tuberculosis drugs. Children take 10 to 20mg/kg per day, not exceeding 0.3g (3 tablets) per day, taken at once.

The more common symptoms include unsteady gait or numbness, tingling, burning sensation or pain in the hands and feet (peripheral neuritis); dark urine, yellowing of eyes or skin (hepatotoxicity, with an increased incidence of hepatotoxicity in patients over 35 years old); poor appetite, abnormal fatigue or weakness, nausea or vomiting (prodromal symptoms of hepatotoxicity). The rarest symptoms include blurred vision or decreased vision, with or without eye pain (optic neuritis); fever, rash, hematocrit and male breast development. This product may occasionally cause convulsions due to neurotoxicity.

It is contraindicated for patients with abnormal liver function, mental illness and epilepsy.

Precautions for children: Use strictly according to the dosage and usage for children. Precautions for pregnancy and lactation: (1) This product can cross the placenta, resulting in a higher fetal blood concentration than the maternal blood concentration. Animal experiments have confirmed that isoniazid can cause stillbirth, but this has not been confirmed in humans. Pregnant women must fully weigh the pros and cons when using it. The effects of isoniazid on the fetus when combined with other drugs have not yet been clarified. In addition, adverse reactions should be closely observed when using the drug in newborns. (2) The concentration of isoniazid in breast milk can reach 12 mg/L, which is similar to the blood concentration. Although it has not been confirmed to be a problem in humans, the pros and cons should still be fully weighed when using it during lactation. If the drug is used, breastfeeding should be stopped. Precautions for the elderly: The incidence of hepatitis caused by this product is higher in patients over 50 years old.

(1) Drinking alcohol every day while taking isoniazid can easily cause liver toxicity induced by this drug and accelerate the metabolism of isoniazid. Therefore, the dosage of isoniazid needs to be adjusted and signs of liver toxicity need to be closely observed. Patients should be advised to avoid alcoholic beverages while taking the drug. (2) Aluminum-containing antacids can delay and reduce the absorption of isoniazid after oral administration, thereby reducing blood drug concentrations. Therefore, it is necessary to avoid taking both at the same time, or take isoniazid at least 1 hour before taking oral antacids. (3) When anticoagulants (such as coumarin or indandione derivatives) are used simultaneously with isoniazid, the anticoagulant effect is enhanced due to the inhibition of the enzymatic metabolism of the anticoagulant. (4) When taken simultaneously with cycloserine, it can increase central nervous system adverse reactions (such as dizziness or drowsiness). The dosage needs to be adjusted and signs of central nervous system toxicity need to be closely observed, especially for those who need to work.

Keep away from light and store in sealed container.

Isoniazid 0.1g, vitamin B65mg

36 months

Teyi Pharmaceutical Group Co., Ltd.

• Founded in:

  2002-05-23

• Address:

  No. 9, 11, Changxing Road, Taicheng, Taishan City

• Tax NO.:

  91440700738598678Q

• Registered Funds:

  510.788782 million yuan

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