Children's Trimethoprim-Bis-sulfuron Granules

1. Pharmacology This product has good antibacterial effects on non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Proteus, Morganella, Shigella and other Enterobacteriaceae, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, especially the antibacterial effect on Escherichia coli, Haemophilus influenzae, and Staphylococcus aureus is significantly enhanced compared with SMZ alone. In addition, it also has good antimicrobial activity against Chlamydia trachomatis, Nocardia asteroides, protozoa, Toxoplasma, etc. in vitro. The mechanism of action of this product is that SMZ and SD act on dihydrofolate synthase, interfering with the synthesis of folate reductase. The synthesis of the two can double block the folic acid metabolism of bacteria. The synergistic antibacterial effect of this product is stronger than that of a single drug, and the number of strains resistant to it is reduced. However, in recent years, bacterial resistance to this product has also shown an increasing trend. 2. Toxicology: Acute toxicity, chronic toxicity and gastrointestinal irritation tests; oral LD50 for mice is 1.81 mg/g; intraperitoneal injection LD50 for mice is 2.39 mg/g; no irritation to the gastrointestinal tract of rabbits and mice.

This product is a compound preparation, and its components are: each bag contains 0.1g of sulfamethoxazole, 0.1g of sulfadiazine, and 40mg of trimethoprim.

This product is white, off-white or slightly yellow granules.

It is used for urinary tract infections, intestinal infections, respiratory tract infections, meningitis, otitis media, carbuncles and sepsis caused by sensitive bacteria.

Oral administration: 6-12 months, 0.5 bag at a time; 1-2 years old, 0.5-1 bag a day; 3-5 years old, 1-1.5 bags a day; 6-8 years old, 1.5-2 years old at a time; 9-13 years old, 2-3 bags at a time, twice a day or as directed by a doctor.

1. Allergic reactions are relatively common. It can manifest as drug rash. In severe cases, exudative erythema multiforme, exfoliative dermatitis and bullous epidermolysis atrophic dermatitis may occur; there are also serum sickness-like reactions such as photosensitivity reaction, drug fever, joint and muscle pain, fever, etc. Anaphylactic shock is occasionally seen. 2. Neutropenia or deficiency, thrombocytopenia, and occasionally aplastic anemia. Patients may show symptoms of sore throat, fever and bleeding tendency. 3. Hemolytic anemia and hemoglobinuria. This is prone to occur in patients who lack glucose-6-phosphate dehydrogenase after using sulfonamides, and is more common in newborns and children than in adults. 4. Hyperbilirubinemia and neonatal kernicterus. Because this product competes with bilirubin for protein binding sites, it can cause increased free bilirubin. Newborns have imperfect liver function, so they are more likely to...

1. It is contraindicated for patients who are allergic to sulfonamides and trimethoprim. 2. It is contraindicated for patients with megaloblastic anemia. 3. It is contraindicated for patients with severe liver and kidney damage. 4. It is contraindicated for infants under 2 months old.

Precautions for children: It is forbidden for infants under 2 months old. Precautions for pregnancy and lactation: This test has not been conducted and there is no reliable reference data. Precautions for the elderly: This test has not been conducted and there is no reliable reference data.

1. The combined use of urine alkalinizing drugs can increase the solubility of this product in alkaline urine and increase excretion. 2. It cannot be used in combination with para-aminobenzoic acid. Para-aminobenzoic acid can replace this product and be taken up by bacteria, and the two are antagonistic to each other. 3. When the following drugs are used together with this product, this product can replace the protein binding sites of these drugs, or inhibit their metabolism, resulting in prolonged drug action time or toxic reactions. Therefore, when these drugs are used at the same time as this product, or when used after the application of this product, their dosages need to be adjusted. Such drugs include oral anticoagulants, oral hypoglycemic drugs, methotrexate, phenytoin sodium and thiopental sodium. 4. The combined use with bone marrow suppressive drugs may enhance the adverse reactions of such drugs on the hematopoietic system. Such as leukopenia, thrombocytopenia, etc. If there is an indication to use the two drugs together, the possible toxic reactions should be closely observed.

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Sulfadiazine 0.1g, sulfadiazine 0.1g, trimethoprim 40mg

24 months

Yichang Humanwell Pharmaceutical Co., Ltd.

• Founded in:

  2001-08-08

• Address:

  No. 19, Dalian Road, Yichang Development Zone, Hubei Province

• Tax NO.:

  91420500730843405M

• Registered Funds:

  293,527,036 yuan

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