Tiopronin for injection

Tiopronin is a thiol-containing drug with similar properties to penicillamine, which has the function of protecting liver tissue and cells. Animal experiments show that Tiopronin can prevent liver damage caused by carbon tetrachloride, ethionine, acetaminophen, etc. by providing thiol groups, and has an inhibitory effect on the accumulation of triglycerides in chronic liver damage. Tiopronin can reduce the activity of ATPase in liver cell mitochondria, thereby protecting the liver mitochondrial structure and improving liver function. In addition, Tiopronin can also remove free radicals through the reversible binding of thiol groups to free radicals.

The main ingredient of this product is tiopronin, and its chemical name is: N-(2-mercaptopropionyl)-glycine.

This product is white loose mass or powder.

1. Used to improve liver function of various acute and chronic hepatitis. 2. Used to treat fatty liver, alcoholic liver, drug-induced liver damage and detoxify heavy metals. 3. Used to reduce the adverse reactions of radiotherapy and chemotherapy, and prevent peripheral leukopenia caused by radiotherapy and chemotherapy. 4. Used for early senile cataracts and vitreous opacities.

Intravenous drip, 0.2g at a time (two vials of 0.1g; one vial of 0.2g), once a day, for 4 consecutive weeks. Preparation method: Before use, dissolve 0.1g of tiopronin for injection in 2ml of 5% sodium bicarbonate injection (pH=8.5). Then expand the volume to 250-500ml of 5%-10% glucose solution or 0.9% sodium chloride injection, and drip intravenously as usual.

1 This drug may cause all the adverse reactions of penicillamine, but the incidence of its adverse reactions is lower than that of penicillamine. 2 Agranulocytosis is rare in the blood system, and thrombocytopenia is occasionally seen. If the peripheral white blood cell count drops below 3.5×106 per milliliter, or the platelet count drops below 10×106 per milliliter, it is recommended to stop the drug. 3 Proteinuria may occur in the urinary system, with an incidence of about 10%, and it usually recovers quickly after stopping the drug. There are also case reports that this drug can cause urine discoloration. 4 The digestive system may experience loss of taste, abnormal taste, nausea, vomiting, abdominal pain, diarrhea, loss of appetite, flatulence, oral ulcers, etc. There are also reports of bile

The following patients are contraindicated: 1. Patients who are allergic to the ingredients of this product. 2. Patients with severe hepatitis accompanied by complications such as severe jaundice, refractory ascites, gastrointestinal bleeding, etc. 3. Patients with renal insufficiency and diabetes. 4. Pregnant and lactating women. 5. Children. 6. Patients with acute severe lead or mercury poisoning. 7. Patients who have experienced agranulocytosis, aplastic anemia, thrombocytopenia or other serious adverse reactions when using this drug in the past.

Precautions for children: Children are prohibited. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited.

This drug should not be used in combination with drugs that have oxidizing effects.

Keep in a dark and airtight place in a cool place. Valid for 24 months.

0.1g

Dalian Wanda Commercial Management Group Co.,Ltd

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