Flumazenil Injection

Flumazenil is a benzodiazepine receptor antagonist that competitively inhibits the reaction of benzodiazepines with their receptors, thereby specifically blocking their central nervous system effects.

Active ingredient: Flumazenil; Excipients: Disodium ethylenediaminetetraacetate, acetic acid, sodium chloride, water for injection. The chemical name of Flumazenil is 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester.

This product is a colorless clear liquid.

It can be used clinically for benzodiazepine overdose or poisoning and epileptic seizures after anesthesia.

Intravenous injection: 0.3mg ~ 0.6mg each time.

1. A small number of patients may experience facial flushing, nausea and/or vomiting when taking the drug during anesthesia. After a rapid injection of flumazenil, there may occasionally be discomfort such as anxiety, palpitations, fear, etc. These side effects usually do not require special treatment. 2. In people with a history of epilepsy or severe liver dysfunction, especially in those with a history of long-term use of benzodiazepines or in cases of mixed drug overdose, there have been reports of epileptic seizures with the use of this drug. 3. In the case of mixed drug overdose, especially overdose of cyclic antidepressants, the use of this product to reverse the effects of benzodiazepines may cause adverse reactions (such as convulsions and arrhythmias). 4. There are reports that this type of drug may induce panic attacks in patients with a history of panic. 5. For long-term use of benzodiazepines and

1. Those who are allergic to this drug and diazepam, and those who have severe symptoms of antidepressant poisoning; 2. Those who are using benzodiazepines to control status epilepticus or intracranial pressure; 3. Those who have severe antidepressant poisoning. 4. Those who take benzodiazepines for a long time should use with caution.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Do not use this product within 3 months of early pregnancy. Use this product with caution for lactating women. Precautions for the elderly: No special contraindications.

Flumazenil blocks the effects of non-benzodiazepine drugs such as zopiclone and triazolopyridazines that act via benzodiazepine receptors. The pharmacokinetics of benzodiazepine receptor agonists are not affected by flumazenil, and vice versa. Alcohol does not interact with flumazenil.

Keep away from light and store in a sealed container.

5ml:0.5mg

24 months

Jiangsu Nhwa Pharmaceutical Co., Ltd.

• Founded in:

  1999-03-29

• Address:

  No. 18, Yangshan Road, Xuzhou Economic and Technological Development Zone

• Tax NO.:

  913203001363846728

• Registered Funds:

  1016.176792 million yuan

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