Azithromycin dry suspension

Azithromycin is a 15-membered macrolide antibiotic. In vitro tests have shown that azithromycin has antibacterial effects on a variety of common clinical pathogens, including: 1. Gram-positive aerobic bacteria: Staphylococcus aureus, Streptococcus pyogenes (group A beta; hemolytic streptococci), pneumonia (streptococci), alpha; hemolytic streptococci (grass viridans streptococci) and other streptococci, diphtheria (rod-shaped) bacilli. This product shows cross-resistance to erythromycin-resistant Gram-positive bacteria, including fecal streptococci (enterococci) and methicillin-resistant Staphylococcus aureus strains. 2. Gram-negative aerobic bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Acinetobacter, Yersinia, Legionella pneumophila, Bordetella pertussis, Bordetella parapertussis, Shigella, Pasteurella, Vibrio cholerae, Parahaemolyticus, Shigella-like Pseudomonas. The activity of this product against the following Gram-negative bacteria depends on the strain, and sensitivity testing is required: Escherichia coli, Salmonella typhi, Enterobacter, Hydrophila, Klebsiella. Anaerobic bacteria: Bacteroides fragilis, Bacteroides, Clostridium perfringens, Peptostreptococcus, Fusobacterium necroticum, Propionibacterium acnes. 3. Sexually transmitted disease microorganisms: Treponema pallidum, Neisseria gonorrhoeae, Haemophilus dukei. 4. Other microorganisms: including Borrelia tenens (Lyme disease body), Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Chlamydia trachomatis, Pneumocystis carinii, Mycobacterium avium, Campylobacter, Listeria monocytogenes. 5. The following Gram-negative bacteria are usually resistant: Proteus, Serratia, Morganella, Pseudomonas. The mechanism of action is the same as erythromycin, mainly binding to the 50S subunit of the bacterial ribosome, inhibiting RNA-dependent protein synthesis.

The main ingredient of this product is azithromycin.

This product is in the form of granules or powder; it has a fragrant aroma and sweet taste.

This product is suitable for the following infections caused by sensitive bacteria: 1. Bronchitis, pneumonia and other lower respiratory tract infections; 2. Skin and soft tissue infections; 3. Acute otitis media; 4. Sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections (Penicillin is a commonly used drug for the treatment of purulent streptococcal pharyngitis and is also a commonly used drug for the prevention of rheumatic fever. Azithromycin can effectively eliminate streptococci in the oropharynx, but there is currently no data on the efficacy of azithromycin in the treatment and prevention of rheumatic fever). 5. Azithromycin can be used for simple genital infections caused by Chlamydia trachomatis in sexually transmitted diseases between men and women. 6. Azithromycin can also be used for simple genital infections caused by non-multidrug-resistant gonococci and chancroid caused by Haemophilus dukei (co-infection with Treponema pallidum must be excluded).

Take orally once a day. Dissolve in water, stir well before taking, and can be taken with food. Azithromycin dry suspension is used to treat various infectious diseases. The course of treatment and usage are as follows: Adults: 1. For sexually transmitted diseases caused by Chlamydia trachomatis, Haemophilus dukei or sensitive gonococci, only 1.0g of this product is needed orally at a single time. 2. For the treatment of other infections: total dose 1.5g, take 0.5g of this product once a day for three days. Or the total dose is the same, still 1.5g, take 0.5g on the first day, and take 0.25g of this product orally once a day from the second to the fifth day. Patients with renal insufficiency: Patients with mild or moderate renal insufficiency (glomerular filtration rate is 10-80ml/min) do not need to adjust the dosage. Patients with severe renal insufficiency (glomerular filtration rate <10ml/min=) should follow the doctor's advice when taking the medicine. 3. Patients with hepatic insufficiency: For patients with mild to moderate renal insufficiency, the usage and dosage of this product are the same as those with normal liver function.

Gastrointestinal reactions such as abdominal pain, diarrhea (loose stools), upper abdominal discomfort (pain or cramps), nausea, and vomiting may occur after taking the drug, and their incidence is significantly lower than that of erythromycin. Mild to moderate abdominal distension, dizziness, headache, fever, rash, joint pain and other allergic reactions may occur occasionally, while anaphylactic shock, angioedema, and cholestatic jaundice are extremely rare. A small number of patients may experience transient neutropenia and elevated serum aminotransferase.

It is contraindicated in patients who are allergic to azithromycin, erythromycin, or any other macrolide drugs.

Precautions for children: The efficacy and safety of treating otitis media, community-acquired pneumonia in children under 6 months old and pharyngitis or tonsillitis in children under 2 years old have not been determined. Precautions for pregnancy and lactation: Animal experiments show that this product has no effect on the fetus, but there is still a lack of experience in its use in pregnant women, so the pros and cons must be fully weighed before using it in pregnant women. There is no data to show whether this product can be secreted into breast milk, so the use of it in lactating women must be considered with caution. Precautions for the elderly: It is not yet clear.

1. It is not suitable to be taken at the same time with antacids containing aluminum or magnesium, as the latter can reduce the peak blood concentration of this product; if it must be used together, this product should be given 1 hour before or 2 hours after taking the above drugs. 2. When used in combination with theophylline, the concentration of the latter in plasma can be increased, and attention should be paid to detecting the plasma theophylline level. 3. When used in combination with warfarin, attention should be paid to checking the prothrombin time. 4. When used simultaneously with the following drugs, it is recommended to closely observe the patient: Digoxin increases the digoxin level. Ergotamine or dihydroergotamine acute ergot toxicity, symptoms are severe peripheral vasospasm and dysesthesia (pain to touch). Triazolam enhances the pharmacological effect of triazolam by reducing the degradation of triazolam. Cytochrome P450 system metabolizers increase the levels of carbamazepine, terfenadine, cyclosporine, cyclohexylbarbital, and phenytoin in serum. 5. When used in combination with rifabutin, the latter's toxicity will be increased.

Sealed, store in a dry place.

0.1g

24 months

Dalian Tianyu Pharmaceutical Co., Ltd.

• Founded in:

  1997-09-16

• Address:

  Houshi, Jinzhou District, Dalian City, Liaoning Province

• Tax NO.:

  91210213241831622W

• Registered Funds:

  7.01427 million yuan

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