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Tobramycin dexamethasone eye ointment

Function and Efficacy

1. Adrenal cortical hormones can inhibit inflammatory responses caused by various factors and may also delay wound healing. Adrenal cortical hormones inhibit the body's defense against infection. If this inhibitory ability is clinically significant, the combined use of antibiotics should be considered. Dexamethasone is a very strong corticosteroid; 2. The antibiotic component (tobramycin) contained in the mixture has anti-sensitive microorganism activity. Experimental studies have shown that tobramycin is effective against the following microbial sensitive strains: Staphylococcus: Staphylococcus aureus and Staphylococcus epidermidis (coagulase positive and negative), including penicillin-resistant strains. Streptococcus: Group A (hemolytic streptococci, some non-hemolytic streptococci and some pneumococci. Pseudomonas aeruginosa, Escherichia coli, Pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morgaii, most common Proteus strains, Haemophilus influenzae, H. aegyptius, Haemophilus conjunctivitis, Acinctobacter calcoaceticus (Herelle avaginacola) and some Neisseria; 3. Bacterial sensitivity tests show that some microorganisms resistant to gentamicin are still sensitive to tobramycin. No strains with significant resistance to tobramycin have been found. However, resistant bacteria may appear with prolonged use; 4. There is no typical There is no data on the extent of systemic absorption of Dexamethasone after use of Dexamethasone eye drops. However, it is known that systemic absorption occurs after topical ocular administration. If Dexamethasone eye drops are used at the maximum dose (two drops per eye every two hours) during the first 48 hours, complete systemic absorption will occur. This is equivalent to 2.4 mg of dexamethasone per day. The usual physiological replacement is 0.75 mg per day. If Dexamethasone eye drops are applied to both eyes every four hours during the first 48 hours, the amount of dexamethasone used will be 1.2 mg per day. 5. There is no data on the extent of systemic absorption of Dexamethasone eye ointment after use. However, it is known that systemic absorption occurs after topical ocular administration. When Dexamethasone eye ointment is applied to both eyes four times a day, the amount of dexamethasone used will be 0.4 mg per day.

Ingredients

Tobramycin 9 mg and dexamethasone 3 mg.

Name Description Content CAS NO. Manufacturer
TobramycinIngredients

It has activity against sensitive microorganisms. It is effective against the following sensitive strains of microorganisms: Staphylococcus (Staphylococcus aureus and Staphylococcus epidermidis), Streptococcus (Group A hemolytic streptococci, some non-hemolytic streptococci and some pneumococci), Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morgaii, most common Proteus strains, Haemophilus influenzae, H. aegyptius, Haemophilus conjunctivitis, Acinctobacter calcoaceticus (Herelle avaginacola) and some Neisseria. The bacterial susceptibility test showed that some microorganisms resistant to gentamicin are still sensitive to tobramycin.

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32986-56-4 13
DexamethasoneIngredients

Adrenal cortex hormones can inhibit inflammatory responses caused by various factors and may also delay wound healing. Adrenal cortex hormones inhibit the body's defense against infection. If this inhibitory ability is clinically significant, combined use of antibiotics should be considered. Dexamethasone is a very strong corticosteroid.

More
50-02-2 24

Indication

1. Used for eye diseases sensitive to adrenal cortical hormones and external eye bacterial infections. 2. Ophthalmic hormones are used for inflammatory diseases such as eyelids, conjunctiva, cornea, preocular membranes and confirmed infectious conjunctivitis to reduce edema and inflammation. They are also suitable for chronic uveitis, chemical, radioactive, burn and foreign body penetrating corneal injuries and inflammation after ophthalmic surgery such as cataracts. 3. Ophthalmic antibiotics are used to treat and prevent possible external eye bacterial infections.

Usage and Dosage

1. Apply about 1-1.5 cm of ointment into the conjunctival sac 3 to 4 times a day. 2. The first prescription should not exceed 8 grams of eye ointment.

Adverse Reactions

There are allergic reactions, such as itching and redness of the eyelids, and conjunctival erythema.

Precautions

Herpes simplex virus keratitis (dendritic keratitis), vaccinia, chickenpox and other keratitis caused by filterable virus infection, conjunctivitis, mycobacterial infection of the eye, fungal infection of the eye.

Storage

Store at room temperature.

Packaging Specification

Tobramycin 0.3%, dexamethasone 0.1%

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