Racemic Anisodamine Hydrochloride Injection

It has a peripheral anti-M cholinergic receptor effect, can relieve smooth muscle spasms caused by acetylcholine, can also relieve microvascular spasms, and improve microcirculation. It has a relaxing effect on gastrointestinal smooth muscle and inhibits its peristalsis. Its effect is slightly weaker than atropine, and its effect of inhibiting digestive gland secretion is 1/10 of atropine. Its effect of inhibiting salivary gland secretion and dilating pupils is weaker, which is 1/20 to 1/10 of atropine. Because it is not easy to pass through the blood-cerebrospinal fluid barrier, its central effect is also weaker than atropine.

The main ingredient of this product is racemic anisodamine hydrochloride, chemical name: (plusmn;)-6beta;-hydroxy-1alpha;H, 5alpha;H-tropane-3alpha;-ol tropate hydrochloride.

Anti-M cholinergic drugs are mainly used to relieve smooth muscle spasms, gastrointestinal colic, biliary spasm, acute microcirculatory disorders and organophosphorus poisoning.

1 Common dosage: 5-10 mg for adults, 0.1-0.2 mg/kg for children, 1-2 times a day; 2 Anti-shock and organophosphorus poisoning: intravenous injection, 10-40 mg for adults, 0.3-2 mg/kg for children, if necessary, repeat the administration every 10-30 minutes, or increase the dosage. After the condition improves, the dosing interval should be gradually extended until the drug is stopped.

Common symptoms include dry mouth, flushed face, blurred vision, etc.; rare symptoms include rapid heartbeat, dysuria, etc.; the above symptoms usually disappear within 13 hours. Atropine-like poisoning symptoms may occur when the dosage is too large.

It is contraindicated for patients with increased intracranial pressure, acute cerebral hemorrhage, glaucoma, pyloric obstruction, intestinal obstruction and prostatic hypertrophy; it should be used with caution in patients with reflux esophagitis and severe ulcerative colitis.

1. When used in combination with amantadine, phenothiazines, tricyclic antidepressants, primidone, procainamide and other anticholinergic drugs, adverse reactions may increase. 2. When used in combination with monoamine oxidase preparations (including furazolidone and procarbazine), the side effects of antimuscarinic effects may be enhanced. 3. It can weaken gastrointestinal motility and delay gastric emptying, affecting some drugs, such as erythromycin staying in the stomach for too long, reducing the efficacy, delaying the absorption of acetaminophen, and increasing the absorption of digoxin, nitrofurantoin and other drugs.

Sealed storage

1 ml: 2 mg

Anhui Chengshi Pharmaceutical Co., Ltd.

• Founded in:

  2004-04-02

• Address:

  No. 5068 Huaishang Avenue, Bengbu City, Anhui Province

• Tax NO.:

  91340300760812351P

• Registered Funds:

  107.5 million yuan

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