Acyclovir cream
Function and Efficacy
This product is a synthetic nucleoside antiviral drug that can be selectively phosphorylated by the viral thymidine kinase and converted into a monophosphate. The latter is then converted into a diphosphate and a triphosphate by the action of cellular enzymes. Acyclovir triphosphate can interfere with DNA polymerase, especially herpes virus DNA enzyme, thereby inhibiting the replication of viral DNA. In vivo and in vitro experiments have shown that acyclovir has inhibitory effects on herpes simplex virus type Ⅰ (HSV-1), type Ⅱ (HSV-2) and varicella-zoster virus (VZV). Cell culture results show that this product has the strongest effect on inhibiting HSV-1 virus, followed by HSV-2 and VZV virus. Toxicological effects: In rats or Chinese hamsters, the maximum tolerable dose of parenteral administration is 1.5-2.5 mg/kg.
Ingredients
The main ingredient of this product is acyclovir, and its chemical name is: 9-[(2-hydroxyethoxy)methyl]guanine
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| AcyclovirIngredients |
This product is a synthetic nucleoside antiviral drug that can be selectively phosphorylated by the virus's thymidine kinase and converted into a monophosphate, which is then converted into a diphosphate and a triphosphate by the action of cellular enzymes. Acyclovir triphosphate can interfere with DNA polymerase, especially herpes virus DNA enzyme, thereby inhibiting the replication of viral DNA. In vivo and in vitro experiments have shown that acyclovir has an inhibitory effect on herpes simplex virus type Ⅰ (HSV-1), type Ⅱ (HSV-2) and varicella-zoster virus (VZV). Cell culture results show that this product has the strongest effect on inhibiting HSV-1 virus, followed by HSV-2 and VZV virus. More |
59277-89-3 | 50 |
Appearance
This product is a white or off-white ointment with an emulsion base.
Indication
For herpes simplex or herpes zoster infections
Usage and Dosage
Apply to the affected area. For both children and adults, apply once every 4 hours, 5 times a day. Do not use at night. Apply for 5 consecutive days. If the condition is not cured after 5 days, the course of treatment can be extended for an additional 5 days.
Adverse Reactions
After using this product, some patients may experience a short-term burning or tingling sensation. About 40% of patients experience mild dryness and scaly changes in the skin. A few patients have reported erythema and itching.
Precautions
This product is contraindicated in patients with known hypersensitivity to acyclovir or propylene glycol.
Special Population Medication
Precautions for children: The safety and efficacy of acyclovir in pediatric use have not yet been established. Precautions for pregnancy and lactation: Pregnant women and lactating women are prohibited from using or should use with caution. Precautions for the elderly: Elderly people should use with caution due to poor renal function.
Drug Interactions
Clinical experience shows that acyclovir cream has no interaction with other drugs. If you are using other drugs, you should consult a physician or pharmacist before using this product.
Storage
Sealed and stored in a cool place.
Packaging Specification
3%
Validity Period
24 months
Manufacturer
Zhejiang Dubang Pharmaceutical Co., Ltd.
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Founded in:
2010-03-22 -
Address:
No. 26, Bingang Middle Road, Qujiang Economic Development Zone, Quzhou City, Zhejiang Province -
Tax NO.:
91330800552854389A -
Registered Funds:
50 million yuan -
Email: