Acyclovir

Acyclovir, a molecule tailored to inactivate the thymidine kinase of the herpesvirus, is a guanosine analogue antiviral drug. It is a drug for HSV infection by GlaxoSmithKline.IC50 Value: 0.53-0.75 uM [3]Target: HSVin vitro: Acyclovir sensitivity was determined in a plaque-reduction assay in Vero cells. IC50 Values were consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains were 2-10-fold less sensitive than Type 1 strains [2]. in vivo: two patient

• CAS No：

  59277-89-3

• Molecular Formula ：

  C8H11N5O3

• Molecular Mass ：

  225.2

• Exact Mass ：

  225.086182

• PSA ：

  115

• LogP ：

  -1.6

• EINECS ：

  261-685-1

• InChIKeys ：

  MKUXAQIIEYXACX-UHFFFAOYSA-N

• H-bond Acceptor ：

  4

• H-bond Donor ：

  3

• RBN ：

  4

• Appearance ：

  white powder

• Density ：

  1.8±0.1 g/cm3

• Melting Point ：

  256-257°C

• Bolling Point ：

  595°C at 760 mmHg

• Flash Point ：

  302.4±32.3 °C

• Refractive Index ：

  1.762

• Solubility ：

  soluble in 1M HCl at 50mg/ml. soluble in water at 0.7mg/ml. Also soluble in DMSO

• Storage Condition ：

  −20°C

• Vapor Pressure ：

  5.4X10-15 mm Hg at 25 deg C (est)

• Stability ：

  Stable. Incompatible with strong oxidizing agents.

• Hazard Class ：

  IRRITANT

• HS Code ：

  2933990090

• UN No. ：

  NONH for all modes of transport

• WGK_Germany ：

  2

• Risk Code ：

  36/37/38-40-20/21/22

• Safety Instructions ：

  22-24/25-36-26-23

• RTECS No. ：

  UP0791400

• Dangerous Mark ：

  Xi,Xn

• Storage ：

  Treasury is ventilated, low temperature and dry; stored separately from food materials

• P Code ：

  P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P308+P313, P312, P322, P330, P363, P405, P501

• Hazard Statements ：

  H302

• Flammability ：

  Flammable; burning releases toxic nitrogen oxide fumes; drug side effects; allergic dermatitis, dreams, fantasy

• Toxicity ：

  Subcutaneous-rat LD50: 620 mg/kg; peritoneal-rat LD50: 860 mg/kg

• Toxicity Class ：

  moderately

Orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. AntiviralBroad-spectrum antiviral drugs, containing purine nucleus compounds, are converted into triphosphate compounds in the body, interfere with viral DNA polymerase, inhibit viral DNA replication and play an antiviral effect. It has a strong effect on the virus. It is used for the prevention and treatment of viral skin or mucous membrane infections, as well as hepatitis B, herpes simplex keratitis, varicella zoster virus infection, etc.