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Home > Encyclopedia > Acyclovir

Acyclovir

Acyclovir structure
  • CAS No:

    59277-89-3

  • Formula:

    C8H11N5O3

  • Synonyms:

    9-((2-Hydroxyethoxy)methyl)guanine;Aci Sanorania;Aci-Sanorania;Acic;Aciclobeta;Aciclostad;Aciclovir;Aciclovir Alonga;Aciclovir Sanorania;aciclovir von ct

  • China Export:

    From 2018.11 to 2019.11, total export volume of Acyclovir from China was 112,377,052KG while total export value was $2,146,929,254. The biggest proportion of exporting volume in the last 12 months was 9.88% in 2019.03.

  • Categories:

    Pharmaceutical Intermediates  >  Antivirals

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Description

Acyclovir, a molecule tailored to inactivate the thymidine kinase of the herpesvirus, is a guanosine analogue antiviral drug. It is a drug for HSV infection by GlaxoSmithKline.IC50 Value: 0.53-0.75 uM [3]Target: HSVin vitro: Acyclovir sensitivity was determined in a plaque-reduction assay in Vero cells. IC50 Values were consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains were 2-10-fold less sensitive than Type 1 strains [2]. in vivo: two patient

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Basic Attributes

  • 59277-89-3

  • C8H11N5O3

  • 225.2

  • 225.086182

  • 115

  • -1.6

  • 261-685-1

  • MKUXAQIIEYXACX-UHFFFAOYSA-N

  • 4

  • 3

  • 4

Characteristics

  • white powder

  • 1.8±0.1 g/cm3

  • 256-257°C

  • 595°C at 760 mmHg

  • 302.4±32.3 °C

  • 1.762

  • soluble in 1M HCl at 50mg/ml. soluble in water at 0.7mg/ml. Also soluble in DMSO

  • −20°C

  • 5.4X10-15 mm Hg at 25 deg C (est)

  • Stable. Incompatible with strong oxidizing agents.

Safety Information

  • IRRITANT

  • 2933990090

  • NONH for all modes of transport

  • 2

  • 36/37/38-40-20/21/22

  • 22-24/25-36-26-23

  • UP0791400

  • Xi,Xn

  • Treasury is ventilated, low temperature and dry; stored separately from food materials

  • P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P308+P313, P312, P322, P330, P363, P405, P501

  • H302

  • Flammable; burning releases toxic nitrogen oxide fumes; drug side effects; allergic dermatitis, dreams, fantasy

  • Subcutaneous-rat LD50: 620 mg/kg; peritoneal-rat LD50: 860 mg/kg

  • moderately

Usage

Orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. AntiviralBroad-spectrum antiviral drugs, containing purine nucleus compounds, are converted into triphosphate compounds in the body, interfere with viral DNA polymerase, inhibit viral DNA replication and play an antiviral effect. It has a strong effect on the virus. It is used for the prevention and treatment of viral skin or mucous membrane infections, as well as hepatitis B, herpes simplex keratitis, varicella zoster virus infection, etc.

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China Acyclovir Export Data

Data referenced from General Administration of Customs,P.R.China

2018.11-2019.11 China - America  Acyclovir Export Data

From 2018.11 to 2019.11, total export volume of Acyclovir from China to America was 15,218,209KG while total export value was $257,443,342. The biggest proportion of exporting volume in the last 12 months was 13.24% in 2018.11.

2018.11-2019.11 China Acyclovir Export Data

From 2018.11 to 2019.11, total export volume of Acyclovir from China was 112,377,052KG while total export value was $2,146,929,254. The biggest proportion of exporting volume in the last 12 months was 9.88% in 2019.03.

2018.11-2019.11 TOP10 Purchasing Countries' Export Data of Chinese Acyclovir

From 2018.11 to 2019.11, China has exported Acyclovir to 123 countries in total. Country ranks by import volume from high to low is India, America, Brazil, Germany, Korea, Taiwan, Netherlands, Japan, Belgium, Russia. The highest export volume was China to India, accounting for 7.68% of the total volume of China.

Check Export Data for More Purchasing Countries

Purchasing Country Export Volume(KG) Export Percentage Export Value($)

India

15,691,600

7.68%

281,710,903

America

15,218,209

7.44%

257,443,342

Brazil

8,922,475

4.36%

103,596,718

Germany

7,723,379

3.78%

94,692,892

Korea

6,960,493

3.41%

142,914,118

Taiwan

4,743,490

2.32%

47,366,845

Netherlands

4,664,307

2.28%

50,168,618

Japan

4,530,697

2.22%

135,908,869

Belgium

3,284,341

1.61%

57,503,909

Russia

3,237,499

1.58%

52,408,341

Pakistan

2,853,414

1.40%

47,714,424

Canada

2,745,417

1.34%

34,617,177

Vietnam

2,635,692

1.29%

30,722,555

Thailand

2,518,892

1.23%

23,652,161

Israel

2,497,554

1.22%

50,380,166

Italy

2,228,577

1.09%

58,425,125

Australia

1,744,926

0.85%

29,481,703

Mexico

1,657,663

0.81%

32,083,536

Ukraine

1,538,970

0.75%

16,045,444

Iran

1,488,116

0.73%

26,616,943

France

944,633

0.46%

31,751,410

Singapore

857,115

0.42%

13,492,016

Argentina

835,499

0.41%

23,722,700

Spain

809,951

0.40%

36,405,099

Colombia

750,188

0.37%

10,339,127

United Kingdom

721,234

0.35%

19,132,889

Turkey

718,911

0.35%

20,980,713

Saudi Arabia

716,968

0.35%

8,662,060

Poland

673,241

0.33%

21,277,705

South Africa

658,776

0.32%

9,047,486

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