Diclofenac Sodium Sustained Release Capsules (I)

This product is a non-steroidal anti-inflammatory drug. The analgesic and anti-inflammatory effects of this product are through the inhibition of cyclooxygenase to reduce the synthesis of prostaglandins, and it also has a certain effect of inhibiting lipoxygenase to reduce the products of leukotrienes, bradykinin, etc. Acute toxicity test results: the oral LD50 of rats is 150mg/kg; the oral LD50 of mice is 390mg/kg.

The main ingredient of this product is: Diclofenac, chemical name: 2-[(2,6-dichlorophenyl)amino]phenylacetic acid.

Properties: This product is a capsule, and the contents are white or off-white pellets.

1. Relieve acute attacks or persistent joint swelling and pain symptoms of various chronic arthritis such as rheumatoid arthritis, osteoarthritis, spondyloarthropathies, gouty arthritis, rheumatic arthritis, etc.; 2. Various soft tissue rheumatic pains, such as shoulder pain, tenosynovitis, bursitis, myalgia and pain caused by sports injuries, etc.; 3. Acute mild and moderate pains such as pain after surgery, trauma, strain, primary dysmenorrhea, toothache, headache, etc.

Oral administration: This product should be swallowed whole without chewing. 100 mg once a day, or as directed by a doctor.

1. Gastrointestinal reactions: The most common adverse reactions include stomach discomfort, abdominal pain, burning sensation, acid reflux, poor appetite, constipation, nausea, etc. A few patients may experience ulcers, bleeding, and perforation. 2. Nervous system manifestations include headache, dizziness, drowsiness, excitement, etc. 3. It may cause edema, oliguria, electrolyte imbalance and other serious adverse reactions. 4. Other rare adverse reactions include transient increase in serum transaminase, and very few patients may experience jaundice, rash, arrhythmia, granulocytopenia, thrombocytopenia, etc.

Patients with severe liver and kidney dysfunction and hyperallergic constitution are prohibited from using this product. Children should use it with caution. People who are allergic to aspirin or other non-steroidal anti-inflammatory drugs may have cross-allergic reactions to this product. This product may also cause bronchospasm in asthmatic patients who are allergic to aspirin, so it is prohibited for such patients. It is also prohibited for those with anal inflammation.

Precautions for children: This product is not recommended for children under 14 years old. Precautions for pregnancy and lactation: This product can cross the placenta. Animal experiments showed toxicity to fetal mice, but it was not teratogenic. It is forbidden for pregnant and lactating women. Precautions for the elderly: This product can cause or aggravate gastrointestinal bleeding, gastric ulcers and perforations in the elderly, so use with caution.

(1) When used with alcohol or other non-steroidal anti-inflammatory drugs, gastrointestinal adverse reactions increase and there is a risk of ulcers. Long-term use with acetaminophen may increase the toxic side effects on the kidneys. (2) When used with anticoagulants such as heparin and dicoumarol and platelet aggregation inhibitors, there is an increased risk of bleeding. (3) When used with furosemide, the latter's sodium excretion and antihypertensive effects are weakened. (4) When used with verapamil and nifedipine, the blood concentration of this product increases. (5) This product can increase the blood concentration of digoxin, so it is necessary to pay attention to adjusting the dose of digoxin when used together. (6) When used with antidiabetic drugs, this product can affect the efficacy of the latter, so it needs to be considered carefully. (7) When used with antihypertensive drugs, this product can affect the antihypertensive effect of the latter. (8) Probenecid can reduce the excretion of this product, increase the blood concentration, and thus increase toxicity, so it is advisable to reduce the dose of this product when used together. (9) This product can reduce the excretion of methotrexate and increase its blood concentration, even to toxic levels, so this product should not be used with medium or large doses of methotrexate. (10) When used with potassium-sparing diuretics, it can cause hyperkalemia.

Sealed and stored in a cool and dry place. Validity period: tentatively two years.

0.1 g

24 months

Shaanxi Buchang Pharmaceuticals Co., Ltd.

• Founded in:

  2009-11-19

• Address:

  No. 16, Buchang Road, Qindu District, Xianyang City, Shaanxi Province

• Tax NO.:

  91610400694942958R

• Registered Funds:

  25 million yuan

• Website:

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