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Diclofenac

Diclofenac structure

CAS No:
15307-86-5
Formula:
C14H11Cl2NO2
Chemical Name:
Diclofenac
Synonyms:
Benzeneacetic acid,2-[(2,6-dichlorophenyl)amino]-;Acetic acid,[o-(2,6-dichloroanilino)phenyl]-;2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid;N-(2,6-Dichlorophenyl)-o-aminophenylacetic acid;[o-(2,6-Dichloroanilino)phenyl]acetic acid;2-(2,6-Dichloroanilino)phenylacetic acid;Diclofenac acid;Dichlofenac;Diclofenac;2-(2,6-Dichlorophenylamino)phenylacetic acid;Pennsaid;Dicloreuma;Transfenac;Diclomelan;Diclofenamic acid;Diclac;Voltaflan;2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid;Ortofen;DCF 100C;Dicloftil;Voltaren Dolo;Flector EP Tissugel;Flector;Zorvolex;Vetagesic;Zolterol;2-[2-(2,6-Dichloroanilino)phenyl]acetic acid;76595-40-9;87180-41-4
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.

Diclofenac Basic Attributes

Molecular Weight：

278.13

Exact Mass：

296.15

EC Number：

239-348-5

HScode：

2922499990

Characteristics

PSA：

49.3

XLogP3：

3.9

Appearance：

Solid

Density：

1.4±0.1 g/cm3

Melting Point：

156-158 °C

Boiling Point：

412.0±45.0 °C at 760 mmHg

Flash Point：

203.0±28.7 °C

Refractive Index：

1.662

Water Solubility：

4.47e-03 g/L

Storage Conditions：

Diclofenac sodium delayed-release (enteric-coated) tablets, diclofenac sodium extended-release tablets, and diclofenac potassium tablets should be protected from moisture and stored in tight containers at a temperature not exceeding 30 deg C. Commercially available diclofenac sodium and misoprostol tablets should be stored in a dry area at a temperature not exceeding 25 deg C.

Vapor Pressure：

6.14X10-8 mm Hg at 25 deg C (est)

PKA：

4.15None

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

RTECS Number：

AG6310000

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501

Hazard Statements：

H301

Diclofenac Use and Manufacturing

prostaglandin synthetic inhibitor

Computed Properties

Molecular Weight:296.1
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:295.0166840
Monoisotopic Mass:295.0166840
Topological Polar Surface Area:49.3
Heavy Atom Count:19
Complexity:304
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Diclofenac is a non-steroidal anti-inflammatory analgesic derived from phenylacetic acid. Its mechanism of action is to inhibit the activity of cyclooxygenase, thereby blocking the conversion of arachidonic acid into prostaglandins. At the same time, it can also promote the combination of arachidonic acid with triglycerides (triacylglycerols), reduce the concentration of free arachidonic acid in cells, and indirectly inhibit the synthesis of leukotrienes. Diclofenac is a stronger non-steroidal anti-inflammatory drug, and its inhibitory effect on prostaglandin synthesis is stronger than that of aspirin and indomethacin.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Diclofenac Sodium Enteric-Coated Tablets
Ingredients	The main ingredient of this product is diclofenac. Its chemical name is [o-(2,6-dichloroaniline)]phenylacetic acid.
Indication	Diclofenac can increase the plasma concentration of digoxin and lithium-containing preparations and reduce the renal excretion of methotrexate. Therefore, special caution should be exercised when used in combination with these drugs.
Specifications	25mg
Manufacturer	Hainan Pharmaceutical FACTORY Co., Ltd.

Diclofenac Sodium Enteric-Coated Tablets
Ingredients	The main ingredient of this product is diclofenac. Its chemical name is [o-(2,6-dichloroaniline)]phenylacetic acid.
Indication	Diclofenac can increase the plasma concentration of digoxin and lithium-containing preparations and reduce the renal excretion of methotrexate. Therefore, special caution should be exercised when used in combination with these drugs.
Specifications	25mg
Manufacturer	Kaifeng Pharmaceutical (GROUP) Co., Ltd.

Diclofenac Sodium Enteric-Coated Tablets
Ingredients	The main ingredient of this product is diclofenac. Its chemical name is [o-(2,6-dichloroaniline)]phenylacetic acid.
Indication	Diclofenac can increase the plasma concentration of digoxin and lithium-containing preparations and reduce the renal excretion of methotrexate. Therefore, special caution should be exercised when used in combination with these drugs.
Specifications	25mg
Manufacturer	Jilin Wantong Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Amoli Organics Pvt Ltd

United States
Active
YUNG ZIP CHEMICAL IND. CO., LTD.

Taiwan, China
Active
UNIQUE CHEMICALS (A DIV OF J B CHEMICALS AND PHARMACEUTICALS LTD)

United States
Active

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