 Home > Encyclopedia > 1-(2,6-Dichlorophenyl)-2-indolinone

1-(2,6-Dichlorophenyl)-2-indolinone

1-(2,6-Dichlorophenyl)-2-indolinone structure

CAS No:
15307-86-5
Formula:
C14H11Cl2NO2
Chemical Name:
1-(2,6-Dichlorophenyl)-2-indolinone
Synonyms:
Diciofenac;1-(2,6-DICHLOROPHENYL)-1,3-DIHYDRO-INDOLE-2-ONE;(N-1-(2,6-DICHLOROPHENYL) -2-INDOLIN-2-ONE;2-[[2,6-Dichlorophenyl] amino] benzeneacetic acid;1-(2,6-DICHLOROPHENYL)-2-INDOLINONE /MEQUITAZINE;1-(2,6-DICHLOROPHENYL)-2-INDOLINONE/INDOLINONE;DICLOFENAC ACID/[2-(2,6-DICHLORO-PHENYLAMINO)-PHENY]-ACETIC ACID;(o-(2,6-dichloroanilino)phenyl)-acetic acid
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.

ChEBI: Diclofenac is a monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position. It has a role as a non-narcotic analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a xenobiotic, an environmental contaminant, a drug allergen and a non-steroidal anti-inflammatory drug. It is a secondary amino compound, an amino acid, a dichlorobenzene, an aromatic amine and a monocarboxylic acid. It is functionally related to a phenylacetic acid and a diphenylamine. It is a conjugate acid of a diclofenac(1-).

1-(2,6-Dichlorophenyl)-2-indolinone Basic Attributes

Molecular Weight：

296.15

Exact Mass：

296.15

EC Number：

239-348-5

Color/Form：

White to Almost white

HScode：

2922.49.2600

Characteristics

PSA：

49.3

XLogP3：

3.9

Appearance：

Solid

Density：

1.431±0.06 g/cm3(Predicted)

Melting Point：

156-158°

Boiling Point：

412.0±45.0 °C(Predicted)

Flash Point：

203.0±28.7 °C

Refractive Index：

1.662

Water Solubility：

1.278mg/L(30 ºC)

Storage Conditions：

Diclofenac sodium delayed-release (enteric-coated) tablets, diclofenac sodium extended-release tablets, and diclofenac potassium tablets should be protected from moisture and stored in tight containers at a temperature not exceeding 30 deg C. Commercially available diclofenac sodium and misoprostol tablets should be stored in a dry area at a temperature not exceeding 25 deg C.

Vapor Pressure：

6.14X10-8 mm Hg at 25 deg C (est)

PKA：

pKa 4 (Uncertain)

Critical Temperature & Pressure：

Sealed in dry,Room Temperature

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

WGK 3

RTECS Number：

AG6310000

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501

Hazard Statements：

H301

RIDADR：

3249

1-(2,6-Dichlorophenyl)-2-indolinone Use and Manufacturing

prostaglandin synthetic inhibitor

Diclofenac possesses all of the properties unique to the series of propionic acid drugs, yet in terms of anti-inflammatory and analgesic strength it exceeds that of aspirin, analgin, and ibuprofen. It is used in acute rheumatism, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, and myalgia. It rarely causes side effects. The most common synonym is voltaren.

Computed Properties

Molecular Weight:296.1
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:295.0166840
Monoisotopic Mass:295.0166840
Topological Polar Surface Area:49.3
Heavy Atom Count:19
Complexity:304
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Diclofenac is a non-steroidal anti-inflammatory analgesic derived from phenylacetic acid. Its mechanism of action is to inhibit the activity of cyclooxygenase, thereby blocking the conversion of arachidonic acid into prostaglandins. At the same time, it can also promote the combination of arachidonic acid with triglycerides (triacylglycerols), reduce the concentration of free arachidonic acid in cells, and indirectly inhibit the synthesis of leukotrienes. Diclofenac is a stronger non-steroidal anti-inflammatory drug, and its inhibitory effect on prostaglandin synthesis is stronger than that of aspirin and indomethacin.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Diclofenac Sodium Enteric-Coated Tablets
Ingredients	The main ingredient of this product is diclofenac. Its chemical name is [o-(2,6-dichloroaniline)]phenylacetic acid.
Indication	Diclofenac can increase the plasma concentration of digoxin and lithium-containing preparations and reduce the renal excretion of methotrexate. Therefore, special caution should be exercised when used in combination with these drugs.
Specifications	25mg
Manufacturer	Hainan Pharmaceutical FACTORY Co., Ltd.

Diclofenac Sodium Enteric-Coated Tablets
Ingredients	The main ingredient of this product is diclofenac. Its chemical name is [o-(2,6-dichloroaniline)]phenylacetic acid.
Indication	Diclofenac can increase the plasma concentration of digoxin and lithium-containing preparations and reduce the renal excretion of methotrexate. Therefore, special caution should be exercised when used in combination with these drugs.
Specifications	25mg
Manufacturer	Kaifeng Pharmaceutical (GROUP) Co., Ltd.

Diclofenac Sodium Enteric-Coated Tablets
Ingredients	The main ingredient of this product is diclofenac. Its chemical name is [o-(2,6-dichloroaniline)]phenylacetic acid.
Indication	Diclofenac can increase the plasma concentration of digoxin and lithium-containing preparations and reduce the renal excretion of methotrexate. Therefore, special caution should be exercised when used in combination with these drugs.
Specifications	25mg
Manufacturer	Jilin Wantong Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Amoli Organics Pvt Ltd

United States
Active
YUNG ZIP CHEMICAL IND. CO., LTD.

Taiwan, China
Active
UNIQUE CHEMICALS (A DIV OF J B CHEMICALS AND PHARMACEUTICALS LTD)

United States
Active

See More Registered Holders

Recommended Suppliers of 1-(2,6-Dichlorophenyl)-2-indolinone

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Diclofenac

CAS No.: 15307-86-5

Content: 99.00%

Inquiry
Shandong zhishang chemical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Dichloromethane,Linocaine hydrochloride

(o-(2,6-dichloroanilino)phenyl)-acetic acid

CAS No.: 15307-86-5

Inquiry
SUZHOU AUSUN CHEMICAL CO., LTD. Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Diclofenac Acid,Nitrendipine,Propafenone

Diclofenac Acid

CAS No.: 15307-86-5

Content: 99%

Inquiry

Latest News on 1-(2,6-Dichlorophenyl)-2-indolinone

Learn More Other Chemicals

1-(2,6-Dichlorophenyl)-2-indolinone

172371-96-9
2,4-Dichloro-3-methylpyridine

132097-09-7
2,6-Dibromo-3-fluoropyridine

41404-59-5
Triphenylacetic acid Formula

595-91-5
3-Chloro-5-fluoro-4-pyridinecarboxylic acid Formula

514798-03-9
2-CHLORO-4-PHENYLPYRIDINE Formula

42260-39-9
2-Phenyl-4-quinolinecarboxylic acid Structure

132-60-5
(-)-Flurbiprofen Structure

51543-40-9
What is Naproxen sodium

26159-34-2
What is Glycine, N,N-diethyl-, 4-(acetylamino)phenyl ester, hydrochloride (1:1)

66532-86-3

Hot Searches: buy dht online; primobolan buy; buy sr-17018; chemaid; caustic soda pearls supplier; propylene glycol price

Guide of 1-(2,6-Dichlorophenyl)-2-indolinone

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

1-(2,6-Dichlorophenyl)-2-indolinone

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.