Defibrase for injection

Proteolytic enzyme. It can dissolve blood clots, inhibit thrombosis, and improve microcirculation.

Defibrase

This product is white or off-white freeze-dried block or powder, hygroscopic and easily soluble in water.

(1) Acute cerebral infarction, including cerebral thrombosis, cerebral embolism, transient ischemic attack (TIA), and prevention of recurrent cerebral infarction. (2) Myocardial infarction, unstable angina pectoris, and prevention of recurrent myocardial infarction. (3) Vascular diseases of the limbs, including femoral artery embolism, thromboangiitis obliterans, and Raynaud's disease. (4) Blood in a hyperviscosity state, hypercoagulable state, and prethrombotic state. (5) Sudden deafness. (6) Pulmonary embolism.

Before use, dissolve it in an appropriate amount of water for injection or saline, add it to 100ml-250ml of sterile saline, and drip it intravenously for more than 1 hour. Acute attack period: 10 units at a time, once a day, for 3 to 4 consecutive days. Non-acute attack period: 10 units for the first time, 5 to 10 units for maintenance, once a day or every other day, and a course of treatment of two weeks.

Some patients may experience a small amount of bruising, nosebleeds or gum bleeding, or a transient slight increase in GOT or GPT after taking the medicine, which will disappear on their own after stopping the medicine.

Patients with endogenous bleeding tendency and allergic constitution should use with caution. Patients with severe liver and kidney dysfunction are prohibited from using this product. 1 The following patients are prohibited from using this product: ① Those with a history of bleeding diseases. ② Those who have just undergone surgery. ③ Those with bleeding tendency. ④ Those who are using drugs with anticoagulant effect and platelet inhibition (such as aspirin). ⑤ Those who are using antifibrinolytic preparations. ⑥ Those with severe liver or kidney dysfunction and other symptoms such as papillary muscle rupture, ventricular septum perforation, cardiogenic shock, and multiple organ failure. ⑦ Those with a history of allergy to this product. 2 The following patients should use this product with caution: ① Those with a history of drug allergy. ② Those with a history of gastrointestinal ulcer. ③ Those with sequelae of cerebral thrombosis. ④ Elderly patients over 70 years old.

Precautions for the elderly: Use with caution in patients over 70 years old.

When using this product, avoid using it with salicylic acid drugs (such as aspirin). Anticoagulants can enhance the effect of this product and cause unexpected bleeding; antifibrinolytic drugs can offset the effect of this product and are prohibited from being used in combination.

Keep in a dark place, sealed and stored below 10℃.

5 units

Tianjin Biochemical Pharmaceutical Co., Ltd.

• Founded in:

  1980-09-19

• Address:

  No. 269, Huanhe South Road, Tianjin Pilot Free Trade Zone (Airport Economic Zone)

• Tax NO.:

  91120116103294558X

• Registered Funds:

  303.3028 million yuan

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