Propofol Injection

1. This product exerts a sedative and hypnotic effect by activating the GABA receptor-chloride ion complex. At clinical doses, propofol increases chloride ion conduction, and at high doses, it desensitizes GABA receptors, thereby inhibiting the central nervous system and producing sedative and hypnotic effects. Its anesthetic potency is 1.8 times that of sodium thiopental. It has a fast onset and a short duration of action. When injected intravenously at 2.5 mg/kg, the onset time is 30 to 60 seconds, and the duration is about 10 minutes. It wakes up quickly and there is no hangover feeling after waking up. 2. It can inhibit the throat reflex, facilitate intubation, and rarely cause laryngeal spasm. It has an inhibitory effect on the circulatory system. When this product is used for general anesthesia induction, it can cause a drop in blood pressure, a decrease in myocardial blood perfusion and oxygen consumption, a decrease in peripheral vascular resistance, and no significant change in heart rate. Propofol can reduce blood pressure, and the degree of reduction exceeds 40% in some patients. It is particularly obvious for the elderly and weak, and patients with heart failure to reduce blood pressure. The dose should be reduced as appropriate, and the intravenous injection speed should be slowed down. Propofol also has a significant inhibitory effect on respiration and can inhibit the ventilatory response to carbon dioxide, which is manifested as a decrease in tidal volume. It can increase the respiratory rate when awake, and apnea often occurs after intravenous injection. It has no significant effect on bronchial smooth muscle. 3. Propofol can reduce intracranial pressure and intraocular pressure, reduce cerebral oxygen consumption and cerebral blood flow, and postoperative nausea and vomiting are rare, and the analgesic effect is very weak. It has a synergistic effect when used in combination with other central nervous system depressants. The use of propofol can reduce plasma corticosteroid concentrations, but the adrenal cortex responds normally to exogenous corticosteroids. Propofol anesthesia induction produces involuntary muscle movements and convulsions, which are more obvious during light anesthesia.

Propofol. Excipients: soybean oil, egg yolk lecithin, glycerol and sodium hydroxide.

This product is a white milky liquid.

Induction drugs for intravenous general anesthesia, components of "total intravenous anesthesia" or adjuvant drugs for anesthesia.

The use of propofol usually requires the use of analgesics. Propofol can be used as an adjunct to spinal and epidural anesthesia. It is used in conjunction with commonly used premedications, neuromuscular blocking drugs, inhaled anesthetics and analgesics. As a general anesthesia to assist regional anesthesia techniques, the required dose is relatively low. 1. Anesthesia administration. It is recommended that the dose should be adjusted during administration [about 4 ml (40 mg) is administered every 10 seconds for a healthy adult], and the patient's response should be observed until clinical signs indicate that anesthesia is effective. Most adult patients under the age of 55 years old require about 2.0 to 2.5 mg/kg of propofol; the amount required for patients over this age will generally be reduced; the administration rate for ASA grade III and IV patients should be lower, about 2 ml (20 mg) every 10 seconds. 2. Anesthesia maintenance. Propofol can be administered by continuous infusion or repeated single injections to achieve the concentration required for maintaining anesthesia. The administration rate required for continuous infusion varies significantly between individuals, and usually a rate range of 4 to 12 mg/(kg h) can maintain satisfactory anesthesia. Repeated single injections should be given, and the amount should be 2.5ml/25mg) to 5.0ml (50mg) each time according to clinical needs. 3. ICU sedation. When used as a sedative for patients receiving artificial ventilation under intensive care, continuous infusion of propofol is recommended. The infusion rate should be adjusted according to the required sedation depth. Usually, an infusion rate range of 0.3-0.4 mg/kg/hour should be able to achieve satisfactory sedation. 4. Artificial abortion surgery. Anesthesia induction is performed at a dose of 2.0mg/kg before surgery. If the patient has limb movement due to pain during surgery, a supplementary dose of 0.5mg/kg should be able to achieve satisfactory results. Patients over 55 years old should observe the patient's reaction during administration. Usually, the dose required for anesthesia induction may be lower. Propofol injection is not recommended for children. Propofol is not recommended for use as a pediatric sedative. For pediatric anesthesia induction: It is recommended to slowly administer propofol until signs indicate that anesthesia is taking effect. The dose should be adjusted according to age and/or weight. For most patients over 8 years old, anesthesia induction requires about 2.5 mg/kg; the dose required for patients below this age may be larger; lower doses are recommended for children with ASA grades III and IV. For maintenance of anesthesia in children: Propofol is given by infusion or repeated single injections to maintain the required depth of anesthesia. The required administration rate varies significantly between patients. Usually, an administration rate of 4 to 12 mg/(kg·h) can achieve satisfactory anesthetic effects. 5. Administration method. Undiluted propofol injection can be used directly for infusion. When using undiluted propofol injection for direct infusion, it is recommended to use a micropump or infusion pump to control the infusion rate. Propofol injection can also be diluted for use, but it can only be diluted with 5% glucose injection and stored in a PVC infusion bag or infusion bottle. The dilution does not exceed 1:5 (2 mg/ml). Propofol injection used for anesthesia induction can be mixed with 0.5% or 1% lidocaine injection at a ratio of less than 20:1. The diluent should be prepared aseptically and prepared before administration. The diluent is stable for 6 hours.

1. Systemic side effects: Excitement rarely occurs during anesthesia induction, but during the induction period, hypotension and transient respiratory arrest may occur due to dosage, preoperative medication, etc. During the maintenance of anesthesia, intravenous infusion and reduction of the infusion rate of this product are required to correct hypotension. Myoclonus is occasionally seen during induction, with an incidence of about 1%. Pulmonary edema occasionally occurs. During the recovery phase, a few patients may experience nausea, vomiting and headache. After prolonged administration of this product, there are occasional reports of urine discoloration. Rare include bronchospasm, erythema and hypotensive allergy. Occasionally postoperative fever. When used in combination with other anesthetics, sexual excitement may occur. 2. Local side effects: Local pain at the injection site may occur. Occasionally there is transient skin flushing. Thrombosis and phlebitis are rare.

It is contraindicated for patients who are allergic to propofol or its emulsifier components.

Precautions for children: Propofol used in children for induction, whether as an inhaled anesthetic or for maintenance, will cause a slowing of the heart rate, with a decrease of 10% to 20%. However, propofol itself has no significant effect on the function of the sinoatrial node and atrioventricular node, so it should be used with caution in children under three years old. Precautions for pregnancy and lactation: 1. Propofol injection should not be used during pregnancy, but it can be used when terminating pregnancy. 2. Propofol injection should not be used by parturients and lactating women. Precautions for the elderly: It should be administered by intravenous drip to observe the patient's response. For patients over 55 years old, the dose of propofol given for anesthesia induction should be reduced as appropriate.

Animal and clinical experiments have confirmed that propofol has no correlation with inhaled anesthetics and muscle relaxants when used together. When used in combination with diazepam and midazolam, it prolongs sleep time, and opioids enhance their respiratory depressant effects.

This product should be stored at 4-25℃ and cannot be frozen.

50ml:0.5g

36 months

Sichuan Guorui Pharmaceutical Co., Ltd.

• Founded in:

  2005-12-07

• Address:

  North Section of Fenghuang Road, Yujin Town, Qianwei County, Leshan City

• Tax NO.:

  91511123782279383G

• Registered Funds:

  20 million yuan

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