Voglibose Tablets

This product is an oral hypoglycemic drug. Its mechanism of hypoglycemic effect is to inhibit the activity of a-glucosidase in the small intestinal wall cells, delay the degradation of ingested carbohydrates, and thus reduce postprandial blood sugar levels.

The main ingredient of this product is voglibose, and its chemical name is ()-1L-[1(OH),2,4,5/3]-5-[2-hydroxy-1-(hydroxymethyl)ethyl]amino-1-carbon-(hydroxymethyl)-1,2,3,4-cyclohexylfuran. Molecular formula: C10H21NO7, molecular weight: 267.28.

This product is white or slightly yellow tablets.

Improve postprandial hyperglycemia in diabetics. (This product is suitable for patients who have not seen significant effects from diet therapy or exercise therapy, or who have not seen significant effects from oral hypoglycemic drugs or insulin preparations in addition to diet therapy or exercise therapy.)

Generally, adults take 0.2 mg (1 tablet) orally 3 times a day before meals. If the therapeutic effect is not obvious, the dosage can be increased to 0.3 mg (1.5 tablets) after sufficient observation.

1 Serious side effects 1) Hypoglycemia may occur when used in combination with other diabetes drugs (less than 0.1-5%). In addition, there are reports that hypoglycemia may occasionally occur without other diabetes drugs (less than 0.1%). This product can delay the digestion and absorption of disaccharides. If hypoglycemia symptoms occur, sucrose should not be given, but glucose should be given for appropriate treatment. 2) Abdominal distension and increased intestinal gas (less than 0.1-5%) may occur. Due to the increase in intestinal gas, intestinal obstruction-like symptoms may occasionally occur (less than 0.1%). Observe thoroughly and take appropriate measures such as stopping the drug if symptoms occur. 3) Severe liver dysfunction accompanied by jaundice, increased GOT, and GPT may occasionally occur (less than 0.1%). In addition, there are reports that fulminant hepatitis has occurred with similar drugs (acarbose) (less than 0.1%), so observe thoroughly and take appropriate measures such as stopping the drug if abnormalities occur. 4) When administering the drug to patients with severe liver cirrhosis, due to the worsening of hyperammonemia and impaired consciousness (frequency unknown) caused by constipation, etc., bowel movements should be carefully observed, and appropriate measures such as stopping the drug should be taken immediately if any abnormality is found. 2 Other side effects 1) Digestive system: diarrhea, soft stools, abdominal borborygmi, abdominal pain, constipation, loss of appetite, nausea, vomiting, heartburn (incidence rate is less than 0.1-5%), stomatitis, thirst, abnormal taste (less than 0.1%), 2) Allergic symptoms Note 1): rash, itching (incidence rate is less than 0.1%), 3) Liver: increased GOT, GPT, LDH, g-GTP, ALP (incidence rate is less than 0.1-5%), 4) Psychoneural system: headache, dizziness, staggering, drowsiness (incidence rate is less than 0.1%), 5) Others: paralysis, facial edema, blurry eyes, fever, fatigue, weakness, hyperkalemia, increased serum amylase, decreased high-density lipoprotein, sweating, hair loss (incidence rate is less than 0.1-5%), Note 1) If these conditions occur, the drug should be discontinued.

The following patients are prohibited from using this drug: 1. Patients with severe ketosis, diabetic coma or pre-coma. [Since high blood sugar must be quickly adjusted with infusion and insulin, this product is not suitable for them. 2. Patients with severe infection, patients before and after surgery, or patients with severe trauma. [Since blood sugar must be adjusted by injection of insulin, this product is not suitable for them. 3. Patients with a history of allergy to the ingredients of this product.

Precautions for children: The safety of the drug for children has not been established. Precautions for pregnancy and lactation: Pregnant women, parturients and lactating women should use the drug with caution, because the safety of the drug during pregnancy has not been established. Pregnant women or women who may become pregnant can only use the drug when it is determined that the benefits of treatment outweigh the risks. Although lactating women should avoid using the drug as much as possible, breastfeeding should be avoided when the drug must be used. Precautions for the elderly: The elderly usually have decreased physiological functions, so they should start with a small dose and pay attention to the occurrence of blood sugar levels and digestive system symptoms. At the same time, the drug should be used with caution.

Precautions for combined use 1. When using diabetes drugs (such as sulfonamides and sulfonylureas, biguanides, insulin preparations, insulin sensitizers) together: When using insulin and sulfonylureas together, there have been reports of hypoglycemia. Therefore, when using the above drugs together, the possibility of hypoglycemia should be considered and the drug should be administered cautiously from a low dose. 2. When using diabetes drugs together with drugs that enhance or reduce their hypoglycemic effects: 1) Drugs that enhance the hypoglycemic effect of diabetes drugs (beta-blockers, salicylic acid preparations, monoamine oxidase inhibitors, fibrate hyperlipidemia treatment agents, warfarin, etc.) 2) Drugs that reduce the hypoglycemic effect of diabetes drugs (epinephrine, adrenocortical hormones, thyroid hormones, etc.) When the above drugs are used together with this product, the interactions recorded in the precautions for using diabetes drugs together should be noted, and full attention should also be paid to the effects of this product's delayed sugar absorption effect.

Sealed and stored in a dry place at room temperature.

0.2mg

24 months

Zhejiang Jingxin Pharmaceutical Co., Ltd.

• Founded in:

  1999-02-13

• Address:

  No. 800, Xinchang Avenue East Road, Yulin Street, Xinchang County, Zhejiang Province

• Tax NO.:

  91330000704503984N

• Registered Funds:

  861.02914 million yuan

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