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Cephalexin and Trimethoprim Capsules

Function and Efficacy

This product inhibits bacterial transpeptidase, prevents the synthesis of bacterial cell walls, and inhibits or kills bacteria. The combination of cephalexin and trimethoprim improves the antibacterial ability, delays the development of drug resistance, and reduces the oral dose.

Ingredients

Each tablet contains 125mg of cephalexin and 25mg of trimethoprim

Name Description Content CAS NO. Manufacturer
CephalexinIngredients

By inhibiting bacterial transpeptidase, it prevents the synthesis of bacterial cell walls, inhibits or kills bacteria; when used with trimethoprim, it can enhance antibacterial ability, delay the development of drug resistance, and reduce oral dosage

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15686-71-2 33
TrimethoprimIngredients

Compatible with cephalexin to improve antibacterial ability, delay the development of drug resistance, and reduce oral dosage

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738-70-5 44

Appearance

This product is in the form of capsules.

Indication

Used for infections caused by penicillin-resistant Staphylococci, Streptococci, Pneumococci, Escherichia coli, etc.

Usage and Dosage

It is recommended to be taken orally on an empty stomach. Adults take 1-2 tablets at a time, 4 times a day. Children should take a reduced dosage or follow the doctor's advice.

Adverse Reactions

1. Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2. Allergic reactions such as rash and drug fever are rare, and anaphylactic shock may occur occasionally. 3. Neurological reactions such as dizziness, diplopia, tinnitus, and convulsions. 4. Renal damage may occur occasionally during the use of this product. 5. Occasionally, patients have elevated serum aminotransferases and positive Coombs tests. Hemolytic anemia is rare. Neutropenia and pseudomembranous colitis have also been reported. 6. Trimethoprim's interference with folic acid metabolism can produce adverse reactions in the blood system, such as leukopenia, thrombocytopenia or methemoglobin anemia. Generally, leukopenia and thrombocytopenia are mild, and can be recovered by stopping the drug in time. Folic acid preparations can also be added.

Precautions

1. It is contraindicated for patients who are allergic to cephalosporins or penicillin. 2. It is contraindicated for patients who are allergic to trimethoprim. 3. It is contraindicated for newborns and premature infants. 4. It is contraindicated for patients with severe liver and kidney diseases. 5. It is contraindicated for patients with blood diseases.

Special Population Medication

Precautions for children: It is contraindicated for newborns and premature infants. Precautions for pregnancy and lactation: This product can pass through the placenta and be excreted through breast milk, so pregnant and lactating women should use it with caution. Precautions for the elderly: This product has not been tested and there is no reliable reference literature.

Drug Interactions

1. When used in combination with cholestyramine (cholestyramine), the average blood concentration of cephalexin can be reduced. 2. Probenecid can delay the renal excretion of this product, and there are also reports that probenecid can increase the excretion of this product in bile. 3. When bone marrow suppressants are used in combination with this product, the chance of leukopenia and thrombocytopenia increases. 4. This product should not be used simultaneously with anti-tumor drugs 2,4-diaminopyrimidine drugs, nor should it be used between courses of treatment with other folic acid antagonists, because it may cause bone marrow aplasia or megaloblastic anemia. 5. Co-use of cyclosporine can increase renal toxicity.

Storage

Keep in a dark, sealed and cool place

Packaging Specification

Each tablet contains 62.5mg of cephalexin and 12.5mg of trimethoprim

Validity Period

Tentative 24 months

Manufacturer

Jilin Lihua Pharmaceutical Co., Ltd.

  • Founded in:

    1985-05-13
  • Address:

    No. 333, Chuangxin Road, Changchun Hi-Tech Zone
  • Tax NO.:

    91220101124011158P
  • Registered Funds:

    26.1 million yuan
  • Website:

  • Email:

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