L-Carnitine Injection
Function and Efficacy
L-Carnitine is a natural substance in the body that is essential for mammalian energy metabolism. Its main function is to promote lipid metabolism. During ischemia and hypoxia, acyl-CoA accumulates, and long-chain acyl-Carnitine also accumulates in the mitochondria, while free Carnitine decreases due to large-scale consumption. Ischemia and hypoxia lead to a decrease in ATP levels, increased permeability of cell membranes and subcellular membranes, and accumulated acyl-CoA can cause changes in membrane structure, membrane phase collapse, and cell death. In addition, during hypoxia, sugar anaerobic glycolysis is the main process, and the accumulation of fatty acids leads to acidosis, ion disorder, and cell autolysis and death. A sufficient amount of free Carnitine can allow accumulated acyl-CoA to enter the mitochondria, reduce its inhibition of adenine nucleotide translocase, and enable oxidative phosphorylation to proceed smoothly. L-Carnitine is the main energy source for muscle cells, especially myocardial cells. Many tissues and organs such as the brain and kidneys also rely mainly on fatty acid oxidation for energy. Carnitine can also increase the activity of NADH cytochrome reductase and cytochrome oxidase, accelerate the production of ATP, and participate in the detoxification of certain drugs. For various tissue ischemia and hypoxia, L-carnitine improves the energy supply of tissues and organs by increasing energy production. Other functions of L-carnitine include: oxidation of medium-chain fatty acids; oxidation of fatty acid peroxidase; buffering the ratio of bound coenzyme A to free coenzyme A; generating energy from ketones, pyruvate, and amino acids (including branched-chain amino acids), removing the toxicity of excessive coenzyme A, and regulating blood ammonia concentration.
Ingredients
The main ingredient of this product is L-carnitine.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| L-carnitineIngredients |
Promote lipid metabolism, increase energy production, improve energy supply of tissues and organs, participate in fatty acid oxidation and drug detoxification, buffer the ratio of bound coenzyme A and free coenzyme A, remove excessive coenzyme A toxicity, and regulate blood ammonia concentration. More |
541-15-1 | 17 |
Indication
L-Carnitine deficiency secondary to chronic maintenance hemodialysis in end-stage uremia.
Usage and Dosage
Intravenous injection: At the end of each hemodialysis, dilute 1g of this product with 15ml of normal saline and slowly inject it intravenously for 2 to 3 minutes; or intravenous drip, 50mg/kg; the maximum dose is 0.3g/kg/day.
Adverse Reactions
Nausea, vomiting, diarrhea and transient elevation of alanine aminotransferase may occur occasionally.
Precautions
It is contraindicated for those who are allergic to this product.
Storage
Protect from light and store tightly closed at room temperature.
Packaging Specification
5ml:1g
Manufacturer
Changchun Xiangtong Pharmaceutical Co., Ltd.
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Founded in:
2003-12-12 -
Address:
No. 358, Tongyou Road, Industrial North District, Jiutai Economic Development Zone, Changchun -
Tax NO.:
9122018175615056XD -
Registered Funds:
16.88 million yuan -
Website:
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Email: