Miconazole nitrate cream

Miconazole is a synthetic I-phenethylimidazole derivative and a broad-spectrum antifungal drug. It has inhibitory and killing effects on dermatophytes, Candida, Escherichia and other algae, ascomycetes, cryptococci, etc. It also has strong antibacterial activity against Gram-positive cocci and bacilli. Miconazole acts on the bacterial cell membrane, changes its permeability, prevents nutrient uptake, and causes its death. This product is slightly soluble in methanol, slightly soluble in chloroform or ethanol, and insoluble in water and ether. Most clinically isolated fungi can be inhibited at concentrations below 4 mg/L. In addition, miconazole is also effective against Staphylococcus aureus, Streptococcus, Gram-positive cocci, and anthrax.

Miconazole nitrate

This product is a white or off-white ointment with an emulsion base.

Used for tinea corporis, tinea cruris, tinea manuum, tinea pedis, tinea versicolor, fungal paronychia, and candidal vaginitis caused by dermatophytes, yeasts, and other fungi

For external use, apply to the clean affected area once in the morning and evening; for tinea versicolor, apply once a day. Continue to use the medicine for 7 days after the symptoms disappear to prevent recurrence.

A few patients may experience burning and irritation. Allergic reactions are rare.

People who are allergic to this product

Precautions during pregnancy and lactation: 1. Precautions during pregnancy and lactation Animal tests have shown that miconazole is toxic to the fetus, so pregnant women are prohibited from using this product. 2. It is not clear whether this product will be secreted into breast milk, so it is not recommended for lactating women to use this product.

1. When this product is used in combination with anticoagulants such as coumarin or indandione derivatives, it can enhance the effects of such drugs and lead to prolonged prothrombin time. Patients should be closely observed, prothrombin time should be monitored, and the dose of anticoagulants should be adjusted. 2. This product can increase the blood concentration of cyclosporine and may increase the risk of nephrotoxicity. When the two drugs are used in combination, the blood concentration of cyclosporine should be monitored. 3. Rifampicin can enhance the metabolism of this product and increase liver toxicity. When used in combination, it can reduce the blood concentration of this product and lead to treatment failure. When used in combination with isoniazid, it can also reduce the blood concentration of this product. Therefore, the above drugs should be used in combination with caution. 4. The combination of phenytoin sodium and this product can cause changes in the metabolism of the two drugs and delay the peak time of this product. When the two drugs are used in combination, their reactions should be closely observed. 5. When this product is used in combination with hypoglycemic drugs, it can cause severe hypoglycemia due to inhibition of the latter's metabolism. 6. This product is contraindicated when used in combination with cisapride, because it inhibits the cytochrome P-450 metabolic pathway and can cause heart rhythm disorders. 7. This product is also at risk of arrhythmia if used in combination with astemizole or terfenadine, so it should also be avoided.

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2%

60 months

Three Pharmaceutical Drug Group (Wuhu) Co., Ltd.

• Founded in:

  2005-11-10

• Address:

  China (Anhui) Pilot Free Trade Zone Wuhu Area Jiuhua North Road Biopharmaceutical Technology Park

• Tax NO.:

  91340207781090474X

• Registered Funds:

  15 million yuan

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