Amoxicillin and clavulanate potassium (4:1) dry suspension

This product is a compound preparation composed of amoxicillin and potassium clavulanate, in which amoxicillin is a semi-synthetic broad-spectrum penicillin antibiotic that mainly acts on the bacterial reproduction stage by inhibiting the biosynthesis of its cell wall mucopolypeptide. It is effective against many Gram-positive and Gram-negative bacteria. Potassium clavulanate has a β-lactam structure similar to penicillin. It has only weak antibacterial activity itself, but it can inactivate enzymes produced by many bacteria by blocking the active site of β-lactamase, especially for clinically important, plasmid-mediated β-lactamases (these enzymes are usually related to changes in resistance to penicillins and cephalosporins). The combination of the two can protect amoxicillin from hydrolysis and destruction by β-lactamase, so that it is still effective against resistant bacteria that produce β-lactamase.

This product is a compound preparation, its components are: Amoxicillin 250mg Clavulanic acid 62.5mg

This product is white or off-white powder.

This product is suitable for various infections caused by sensitive bacteria, such as: 1. Upper respiratory tract infections: sinusitis, tonsillitis, pharyngitis, otitis media, etc. 2. Lower respiratory tract infections: acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia, lung abscess and bronchiectasis combined with infection, etc. 3. Urinary system infections: cystitis, urethritis, pyelonephritis, prostatitis, pelvic inflammatory disease, gonococcal urinary tract infection and soft chancroid, etc. 4. Skin and soft tissue infections: furuncle, abscess, cellulitis, wound infection, intra-abdominal sepsis, etc. 5. Other infections: osteomyelitis, sepsis, peritonitis and postoperative infection, etc.

Take with cold boiled water. Adult pneumonia and other moderate to severe infections: 625 mg (2 bags) at a time, once every 8 hours, for 7 to 10 days. Other infections: 312.5 mg (1 bag) at a time, once every 8 hours, for 7 to 10 days. Children ① Newborns and infants under 3 months old. Calculated according to amoxicillin, 15 mg/kg per body weight, once every 12 hours. ② Children weighing ≤40 kg. Calculated according to amoxicillin, general infection: 25 mg/kg per body weight, once every 12 hours; or 20 mg/kg per body weight, once every 8 hours. More severe infection: 45 mg/kg per body weight, once every 12 hours; or 40 mg/kg per body weight, once every 8 hours. Course of treatment 7 to 1

1. A small number of patients may experience mild gastrointestinal adverse reactions such as nausea, vomiting, diarrhea and pseudomembranous colitis. If the above adverse reactions occur, take the medicine with meals, and the above reactions will improve or disappear. 2. Urticaria-like rash is occasionally seen. If urticaria and severe measles-like rash occur, the use of this product should be stopped. 3. A very small number of patients show temporary liver function abnormalities.

The product is contraindicated in the following cases: 1. Allergic to any component of this product; 2. Those with a history of allergy to β-lactamase antibiotics such as penicillin.

Precautions for children: See dosage or follow doctor's advice. Precautions for pregnancy and lactation: 1. This product can pass through the placenta, and the concentration in umbilical cord blood is 1/4-1/3 of the maternal blood concentration. It is forbidden for pregnant women. 2. This product can be secreted into breast milk, which may cause allergies in infants and cause diarrhea, rash, Candida infection, etc. Therefore, lactating women should use it with caution or suspend breastfeeding during medication. Precautions for the elderly: Elderly patients should adjust the dosage or medication according to their renal function.

Not yet clear.

Store in a dry place below 25℃, sealed. Validity period: 18 months Once prepared, this product should be placed in a refrigerator (2~8℃). The prepared product must be consumed within 7 days. If there is any left, please discard it.

0.15625 g (0.125 g of C16H19N3O5 flakes and 0.03125 g of C8H9NO5)

24 months

KBN-ZHEJIANG Pharmaceutical Co., Ltd.

• Founded in:

  1982-02-20

• Address:

  No. 340, Yunhai Road, Jiaxing Economic Development Zone, Zhejiang Province

• Tax NO.:

  913304011464602960

• Registered Funds:

  36.5 million yuan

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