Artesunate Tablets
Function and Efficacy
Artesunate tablets are a derivative of target=_blank artemisinin. It acts on the erythrocytic stage of malarial parasites, affects the surface membrane and mitochondrial function of the parasite, blocks its supply of host erythrocyte substances as nutrition and kills the asexual body of malarial parasites. It has a rapid effect and is effective against multidrug-resistant target=_blank malaria. It has a strong and rapid killing effect on the erythrocytic stage of malarial parasites and can quickly control clinical attacks and symptoms. The mechanism of action of artemisinin is not very clear, but it mainly interferes with the mitochondrial function of the surface membrane of malarial parasites. Artemisinin changes the membrane structure of malarial parasites by affecting their ultrastructure in the erythrocytic stage. Due to the effect on the food vacuole membrane of the malarial parasite surface membrane, the malarial parasite's nutrient intake is blocked. When the malarial parasite loses a large amount of cytoplasm and nutrients and cannot be replenished, it will die quickly. Its mode of action is to generate unstable organic free radicals and/or other electrophilic mediators through its internal peroxide (dioxygen) bridge, mediated by the free iron produced after the decomposition of target=_blank hemoglobin, and then form covalent adducts with the protein of malarial parasites, causing the malarial parasite to die. Toxicology: Animal toxicology experiments show that this product has certain embryotoxicity, which manifests as embryo absorption.
Ingredients
Artesunate.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| ArtesunateIngredients |
It acts on the erythrocytic stage of malarial parasites, affects the surface membrane and mitochondrial function of the parasite, blocks its supply of host erythrocyte substances as nutrition, and kills the asexual body of malarial parasites. It has a rapid effect and is effective against multidrug-resistant malaria. It has a strong and rapid killing effect on the erythrocytic stage of malarial parasites, and can quickly control clinical attacks and symptoms. The mechanism of action of artemisinin is mainly to interfere with the mitochondrial function of the surface membrane of malarial parasites, and changes its membrane structure by affecting the ultrastructure of the erythrocytic stage of malarial parasites, blocking the malarial parasite's nutrient intake, causing it to lose a large amount of cytoplasm and nutrients and die. Its mode of action is through its internal peroxide (dioxygen) bridge, mediated by the free iron produced after the decomposition of hemoglobin, to produce unstable organic free radicals and/or other electrophilic mediators, and then form covalent adducts with malarial parasite proteins, causing the malarial parasite to die. More |
88495-63-0 | 11 |
Indication
Antimalarial drug. Suitable for emergency treatment of cerebral malaria and various severe malaria.
Usage and Dosage
Oral administration: 50 mg at a time, double the first dose, twice a day, for 5 consecutive days.
Adverse Reactions
No adverse reactions were observed at the recommended dose.
Precautions
Pregnant women and those who are allergic to this product are prohibited from using it.
Drug Interactions
Not yet clear.
Storage
Keep away from light and store in sealed container.
Packaging Specification
50mg
Manufacturer
KBN-ZHEJIANG Pharmaceutical Co., Ltd.
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Founded in:
1982-02-20 -
Address:
No. 340, Yunhai Road, Jiaxing Economic Development Zone, Zhejiang Province -
Tax NO.:
913304011464602960 -
Registered Funds:
36.5 million yuan -
Website:
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Email: