Mezlocillin Sodium for Injection

This product is a semi-synthetic penicillin antibiotic. It has an antibacterial effect on Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus, Enterobacter, Citrobacter, Serratia, Acinetobacter, and Gram-positive cocci sensitive to penicillin. Large doses have a bactericidal effect. Its antibacterial activity against Escherichia coli, Enterobacter, Klebsiella pneumoniae, Citrobacter, Serratia, and Acinetobacter is stronger than that of carbenicillin and ampicillin; its antibacterial activity against indole-positive Proteus and Pseudomonas aeruginosa is stronger than that of carbenicillin and sulbenicillin; its antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus is similar to that of carbenicillin, and its antibacterial activity against Streptococcus faecalis is superior to that of carbenicillin and sulbenicillin. It has a good antibacterial effect against most anaerobic bacteria such as Bacteroides fragilis. This product has been tested in vitro

Mezlocillin Sodium

This product is white or off-white powder or crystal or loose lump.

It is used for infections of the respiratory system, urinary system, digestive system, gynecological system and reproductive organs caused by sensitive strains of Gram-negative bacilli such as Escherichia coli, Enterobacter, Proteus, such as sepsis, purulent meningitis, peritonitis, osteomyelitis, skin and soft tissue infections, and eye, ear, nose and throat infections.

Intramuscular injection, intravenous injection or intravenous drip. For intramuscular injection, add sterile injection water to dissolve before use. For intravenous injection, usually add 5% glucose sodium chloride injection or 5%-10% glucose injection to dissolve before use. Adults take 2-6g a day, which can be increased to 8-12g for severe infection, and up to 15g. Children take 0.1-0.2g/kg a day based on body weight, which can be increased to 0.3g/kg for severe infection; intramuscular injection 2-4 times a day, intravenous drip once every 6 (8 hours as needed, the dosage depends on the condition, severe cases can be intravenously injected once every 4-6 hours.

The main adverse reactions are: anorexia, nausea, vomiting, diarrhea, local pain after intramuscular injection and rash, which mostly occur during the administration process. Most of them are mild and do not affect the continued use of the drug. In severe cases, the above symptoms are rapidly alleviated or disappear after stopping the drug. In a few cases, serum aminotransferase, alkaline phosphatase and transient increase in eosinophils may occur. Neutropenia and hypokalemia are extremely rare. No serious reactions such as changes in renal function and blood electrolyte disorders were observed.

It is contraindicated for patients who are allergic to penicillin antibiotics.

Precautions for children: Precautions for pregnancy and lactation: This product can enter the fetal blood circulation through the placenta and a small amount is secreted with breast milk. Although there are no reports of serious problems with the use of this product by lactating women, pregnant women and lactating women should still weigh the pros and cons, because its use can sensitize infants and cause diarrhea, rash, Candida infection, etc. Precautions for the elderly: Elderly patients have impaired renal function and need to adjust the dosage.

1. Antibiotics such as chloramphenicol, erythromycin, tetracyclines and antibacterial agents such as sulfonamides can interfere with the bactericidal activity of this product and should not be used in combination with this product, especially in the treatment of meningitis or severe infections that urgently require bactericides. 2. Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product from the kidneys. Therefore, when used in combination with this product, its blood concentration will increase, the excretion time will be prolonged, and the toxicity may also increase. 3. This product is incompatible with heavy metals, especially copper, zinc and mercury, because the latter can destroy its oxidized thiazole ring. Rubber tubes or bottle stoppers made of zinc compounds can also affect its activity. It can also be inactivated by oxidants, reducing agents or hydroxyl compounds. 4. Cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, and amphotericin are added to the intravenous infusion of this product.

Sealed, store in a dry, cool, dark place.

1.0g (calculated according to C21H25N5O8S2)

Qingzhou Yaowang Pharmaceutical Co., Ltd.

• Founded in:

  1992-12-21

• Address:

  No. 799, Wangmugong Street, Qingzhou Economic Development Zone, Weifang City, Shandong Province

• Tax NO.:

  91370781613582541Q

• Registered Funds:

  335.8311 million yuan

• Website:

  Log in to view

• Email:

  Log in to view