Amoxicillin and Clavulanate Potassium Granules

1This product is a compound preparation of amoxicillin and potassium clavulanate. Amoxicillin is a broad-spectrum penicillin antibiotic. Potassium clavulanate itself has only weak antibacterial activity, but has a strong broad-spectrum β-lactamase inhibitory effect. The combination of the two can protect amoxicillin from β-lactamase hydrolysis. 2The antibacterial spectrum of this product is the same as that of amoxicillin, and has been expanded. It has a good effect on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative Staphylococci and enterococci. It also has good antibacterial activity against some β-lactamase-producing Enterobacteriaceae, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides fragilis, etc. This product has no effect on methicillin-resistant Staphylococci and Enterobacter, which produce chromosome-mediated type I enzymes, Enterobacteriaceae and Pseudomonas.

Amoxicillin, Clavulanate Potassium

Properties: This product is white or off-white suspension granules with aromatic odor and sweet taste.

This product is suitable for various infections caused by sensitive bacteria, such as: 1. Upper respiratory tract infections: sinusitis, tonsillitis, pharyngitis, otitis media, etc. 2. Lower respiratory tract infections: acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia, lung abscess and bronchiectasis combined with infection, etc. 3. Urinary system infections: cystitis, urethritis, pyelonephritis, prostatitis, pelvic inflammatory disease, gonococcal urinary tract infection and soft chancroid, etc. 4. Skin and soft tissue infections: furuncle, abscess, cellulitis, wound infection, intra-abdominal sepsis, etc. 5. Other infections: osteomyelitis, sepsis, peritonitis and postoperative infection, etc.

Oral: Adults and children over 12 years old, 2 packets each time, three times a day. 7-12 years old children, 1.5 packets each time, three times a day. 1-7 years old children, 1 packet each time, three times a day. 3 months-1 year old children, half a packet each time, three times a day. In case of severe infection, the dose can be doubled or as directed by the doctor. Without reexamination, the continuous treatment period shall not exceed 14 days.

1. A small number of patients may experience mild gastrointestinal side effects such as nausea, vomiting and diarrhea. If these side effects occur, they can be restored to normal by taking the medicine at the beginning of a meal. 2. Urticaria and morbilliform rash are occasionally seen. If urticaria and severe morbilliform rash occur, the use of this product should be stopped. 3. Temporary liver function abnormalities may be seen in a very small number of patients.

Contraindicated in patients allergic to penicillin.

Precautions for children: See [Usage and Dosage]. Precautions for pregnancy and lactation: 1. This product can pass through the placenta, and the concentration in umbilical cord blood is 1/4 to 1/3 of the maternal blood concentration, so pregnant women are prohibited from using it. 2. This product can be secreted into breast milk, which may sensitize infants and cause diarrhea, rash, Candida infection, etc., so lactating women should use it with caution or suspend breastfeeding during medication. Precautions for the elderly: Elderly patients should adjust the dosage or medication interval according to their renal function.

1. Aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product in the renal tubules, thereby increasing the blood concentration of this product, prolonging the blood elimination half-life (t1/2beta;), and possibly increasing toxicity. 2. When this product is used in combination with allopurinol, the incidence of rash increases significantly, so it should be avoided. 3. This product should not be used in combination with acetaldehyde dehydrogenase inhibitors such as disulfiram. 4. When this product is used in combination with chloramphenicol for bacterial meningitis, the incidence of long-term sequelae is higher than when either is used alone. 5. This product can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives. 6. Antibiotics such as chloramphenicol, erythromycin, tetracyclines, and antibacterial drugs such as sulfonamides can interfere with the bactericidal activity of this product, so it should not be used in combination with this product, especially in the treatment of meningitis or severe infections that urgently require bactericidal drugs. 7. This product can enhance the effect of warfarin. 8Aminoglycoside antibiotics can generally enhance the in vitro bactericidal effect of this product on Enterococcus faecalis at sub-inhibitory concentrations. 9Since the absorption of this product in the gastrointestinal tract is not affected by food, it can be taken on an empty stomach or after a meal, and can be taken with milk and other foods; taking it with food can reduce gastrointestinal reactions.

Keep in a dark place, sealed and protected from light. Valid for two years.

0.15625g (C16H19N3O5S 0.125g and C8H9NO5 0.03125g)

24 months