Acetaminophen Injection
Function and Efficacy
This product is an acetanilide antipyretic analgesic. It inhibits the prostaglandin synthase in the hypothalamic temperature regulation center, reduces the synthesis and release of prostaglandin PGE1, causes peripheral vasodilation and sweating, and achieves an antipyretic effect. Its antipyretic effect is similar to that of aspirin; it inhibits the synthesis and release of prostaglandins PGE1, bradykinin and histamine, increases the pain threshold and plays an analgesic role. It is a peripheral analgesic, weaker than aspirin, and is only effective for mild and moderate pain. This product has no obvious anti-inflammatory effect. Acute toxicity test results: The oral LD50 of mice is 338mg/kg, and the intraperitoneal injection LD50 is 500mg/kg.
Ingredients
Acetaminophen. Its chemical name is N-(4-hydroxyphenyl)acetamide.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| AcetaminophenIngredients |
This product is an acetanilide antipyretic analgesic. It inhibits the prostaglandin synthase in the hypothalamic temperature regulation center, reduces the synthesis and release of prostaglandin PGE1, causes peripheral vasodilation and sweating, and achieves an antipyretic effect; it inhibits the synthesis and release of prostaglandin PGE1, bradykinin and histamine, increases the pain threshold and has an analgesic effect. It is a peripheral analgesic, weaker than aspirin, and is only effective for mild and moderate pain. This product has no obvious anti-inflammatory effect. More |
103-90-2 | 68 |
Indication
It is used for fever and can also be used to relieve mild to moderate pain, such as headache, muscle pain, joint pain, neuralgia, dysmenorrhea, cancer pain and postoperative analgesia. This product can be used for patients who are allergic to or cannot tolerate aspirin. This product is ineffective for various severe pains and visceral smooth muscle colic.
Usage and Dosage
Intramuscular injection of 0.15g ~ 0.25g. This product should not be used for a long time. The antipyretic course should not exceed 3 days, and the analgesic course should not exceed 10 days.
Adverse Reactions
At conventional doses, acetaminophen has few adverse reactions, and may occasionally cause nausea, vomiting, sweating, abdominal pain, pale skin, etc. In a few cases, allergic dermatitis (rash, itchy skin, etc.), granulocytopenia, thrombocytopenia, anemia, liver damage, etc. may occur, and it rarely causes gastrointestinal bleeding.
Precautions
It is contraindicated for patients who are allergic to this product or have severe liver and kidney dysfunction.
Drug Interactions
1. Long-term use of this product by patients who drink or use other liver enzyme inducers, especially barbiturates or anticonvulsants, may increase the risk of liver toxicity. 2. When used in combination with chloramphenicol, this product can prolong the half-life of the latter and enhance its toxicity. 3. When used in combination with anticoagulants, it can enhance the anticoagulant effect, so the dosage of anticoagulants should be adjusted. 4. When used in combination with aspirin and other non-steroidal anti-inflammatory drugs for a long time, there is a significant risk of increased renal toxicity. 5. When used in combination with the antiviral drug Zidovudine, this product can increase its toxicity and should be avoided at the same time.
Storage
Keep away from light and store in a sealed container.
Packaging Specification
1ml:75mg
Manufacturer
Chengdu Hepatunn Pharmaceutical Co., Ltd.
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Founded in:
2010-12-07 -
Address:
No. 222, Liutai Avenue, Chengdu Cross-Strait Science and Technology Industrial Development Park, Wenjiang District, Chengdu -
Tax NO.:
91510115564494843U -
Registered Funds:
40 million yuan -
Website:
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Email: