Amoxicillin and clavulanate potassium dispersible tablets (14:1)

Pharmacological action: This product is a compound preparation composed of amoxicillin and potassium clavulanate in a ratio of 14:1. Amoxicillin and ampicillin have similar anti-sensitive microbial effects, mainly acting on the reproduction stage of microorganisms by inhibiting the biosynthesis of cell wall mucopolypeptides; potassium clavulanate has a β-lactam structure similar to penicillin, and can inactivate most of the enzymes produced by bacteria by blocking the active site of β-lactamase, especially for clinically important, plasmid-mediated β-lactamases (these enzymes are usually related to changes in resistance to penicillins and cephalosporins). 1 In vitro tests and clinical use results have shown that this compound is effective against most of the following microorganisms: (1) Gram-positive

This product is a compound preparation. Each tablet contains 600 mg of amoxicillin (calculated as C16H19N3O5S) and 43 mg of potassium clavulanate (calculated as C8H9NO5).

This product is off-white or light yellow tablets; it is hygroscopic.

This product is suitable for recurrent or refractory acute otitis media in children caused by Streptococcus pneumoniae, Haemophilus influenzae (including β-lactamase-producing strains), and Moraxella catarrhalis (including β-lactamase-producing strains).

Usage: This product can be dispersed in water and then taken, or it can be swallowed directly with water. Dosage: 90 mg per kilogram of body weight per day, divided into 2 doses, for 10 days. Or follow the doctor's advice.

1. A small number of patients may experience mild gastrointestinal adverse reactions such as nausea, vomiting, diarrhea and pseudomembranous colitis. If the above adverse reactions occur, take the medicine with meals, and the above reactions will improve or disappear. 2. Urticaria-like rash is occasionally seen. If urticaria and severe measles-like rash occur, the use of this product should be stopped. 3. A very small number of patients show temporary liver function abnormalities.

The product is contraindicated in the following cases: 1. Allergic to any component of this product; 2. Those with a history of allergy to β-lactamase antibiotics such as penicillin.

1. After combined use with chloramphenicol, in vitro tests showed that the effects on influenza bacilli were different. 2. Combined use with allopurinol can increase the incidence of rash reactions, especially hyperuricemia. 3. This product can stimulate estrogen metabolism or reduce enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives.

Seal and store in a cool, dark and dry place. Validity period: 24 months

Amoxicillin 0.6g and potassium clavulanate (calculated as clavulanic acid) 43mg

Simcere Pharmaceutical Co., Ltd.

• Founded in:

  1998-09-10

• Address:

  No. 99, Huakang Road, Jiangbei New District, Nanjing, Jiangsu Province

• Tax NO.:

  91320100135665907G

• Registered Funds:

  1.60281382 million yuan

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