Cephalexin effervescent tablets

This product is a semi-synthetic cephalosporin broad-spectrum antibiotic. The antibacterial spectrum is similar to that of cephalothin, but the antibacterial activity is poorer than that of cephalothin. This product is stable to the penicillinase produced by Staphylococcus aureus, so it has a good antibacterial effect on penicillin-resistant Staphylococcus aureus. Except for Enterococcus and methicillin-resistant Staphylococcus, most Gram-positive cocci are sensitive to this product. This product has a good antibacterial effect on Neisseria, and has antibacterial effects on some Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, and Salmonella; it has a poor effect on Haemophilus influenzae; other Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis are resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.

The main ingredient of this product is cephalexin, and its chemical name is (6R,7R)-3-methyl-7-[(R)-2-amino-2-phenylacetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate.

This product is a light yellow tablet with small yellow dots scattered on the surface. It is easily soluble in water and has a sweet taste.

This product is suitable for mild and moderate acute tonsillitis, pharyngitis, otitis media, sinusitis, bronchitis, pneumonia and other respiratory tract infections, urinary tract infections and skin and soft tissue infections caused by sensitive bacteria.

Put this product into warm water and drink it after it dissolves. Oral administration for adults: 0.25-0.5g once every 6 hours. The highest dose is 4g per day. For patients with simple cystitis, skin and soft tissue infections and streptococcal pharyngitis, take 500mg once every 12 hours. For children, take 25-50mg/kg per day according to body weight, once every 6 hours. For patients with skin and soft tissue infections and streptococcal pharyngitis, take 12.5-50mg/kg according to body weight, once every 12 hours.

1. Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2. Allergic reactions such as rash and drug fever. 3. Nervous system reactions such as dizziness, diplopia, tinnitus, convulsions, etc. 4. Transient renal damage may occasionally occur during the use of this product. 5. Occasionally, patients have elevated serum aminotransferase and positive Coombs test. Hemolytic anemia is rare, and neutropenia and pseudomembranous colitis have also been reported.

Patients who are allergic to this product or other cephalosporins are contraindicated.

Precautions for children: Not clear yet. Precautions for pregnancy and lactation: Data show that after pregnant women take 500 mg of this product orally, effective concentrations can be obtained in amniotic fluid and umbilical cord blood, so pregnant women are prohibited from using it; after lactating women take 500 mg of this product orally, the concentration in breast milk is about 5 mg/L, so lactating women should use it with caution or stop breastfeeding. Precautions for the elderly: Elderly patients should adjust the dosage or medication interval according to their renal function under the guidance of a physician.

1. Furosemide, ethacrynic acid, bumetanide and other strong diuretics, carmustine, streptozocin and other antineoplastic drugs, aminoglycoside antibiotics and other nephrotoxic drugs may increase nephrotoxicity when used in combination with this product. 2. Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to this product due to the production of beta-lactamase. 3. Probenecid can delay the excretion of this product through the kidneys, prolonging the blood elimination half-life (t1/2) of this product to 107 minutes; however, there are also reports that probenecid can increase the excretion of this product in the bile. 4. When this product is used in combination with cholestyramine (cholestyramine), the average peak blood concentration of this product can be reduced.

Keep away from light, seal tightly and store in a cool dark place.

0.25g (calculated as C16H17N3O4S)

24 months

Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd.

• Founded in:

  1993-01-30

• Address:

  No.1 Nanshi Road, Haizhu District, Guangzhou

• Tax NO.:

  914401011904851166

• Registered Funds:

  55.285 million yuan

• Website:

  Log in to view

• Email:

  Log in to view