Amoxicillin Sodium and Sulbactam Sodium for Injection

It is a thioxanthene derivative with a strong dopamine receptor blocking effect. In addition to blocking D1 and D2 receptors, it can also inhibit D2 autoreceptors and increase the DA concentration between synapses. It has no sedative effect. Its antipsychotic effect is 4 to 8 times stronger than that of Telden. In addition, it also has antidepressant and antianxiety effects.

Flupenthixol dihydrochloride

White flakes

The effect is stronger than that of aminosulfone thiothioxanthene. It can be used for acute and chronic schizophrenia. Its decanoate is a long-acting agent. It is suitable for negative symptoms of schizophrenia such as apathy and withdrawal, and also has a certain effect on those with anxiety and lack of motivation. Its decanoate long-acting preparation is often used for the maintenance treatment of chronic schizophrenia patients. 533 cases were reported abroad, with a significant efficacy of 41% to 55%. Shanghai Mental Health Center treated 60 chronic patients with a course of more than 5 years, and found that 25 cases (41.7%) had moderate efficacy or above after 3 months of treatment.

The usual dose is 1 mg twice a day, with an increase of 500 μg each time, up to a maximum of 3 mg per day. The dosage can be reduced for the elderly.

Extrapyramidal symptoms are common. They are mainly extrapyramidal reactions, with occasional transient insomnia. Long-term use of the drug may cause tardive dyskinesia.

Patients with impaired heart, liver and kidney function, those with a history of epilepsy, and pregnant women should use it with caution. Although it has no sedative effect, it can affect driving and operating machinery, so you should be careful when using it. Patients with alcohol poisoning, drug poisoning, coma and heart failure should not use this product. This product should not be used in overly excited or overactive patients.

Large doses can increase the effects of ethanol, barbiturates and other central nervous system depressants. It can block the antihypertensive effect of guanethidine and weaken the effects of levodopa and adrenaline. Combination with metoclopramide and piperazine can increase the occurrence of extrapyramidal symptoms.

Sealed storage

0.375 g (0.25 g amoxicillin and 0.125 g sulbactam)

North China Pharmaceutical Company.Ltd

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  1992-12-20

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