Escitalopram Oxalate Tablets

Escitalopram enhances the effects of 5-hydroxytryptamine (5-HT) in the central nervous system and inhibits the reuptake of 5-hydroxytryptamine. It is clinically used to treat depression. Animal studies have shown that escitalopram is a selective serotonin reuptake inhibitor (SSRI), but has a weak effect on the reuptake of norepinephrine and dopamine, which is 100 times that of the dextrorotatory enantiomer of citalopram. Escitalopram has no or very little effect on 5-hydroxytryptamine 1-7 receptors or other receptors including alpha and beta adrenaline, dopamine 1-5, histamine 1, muscarinic 1-5 and benzodiazepine receptors. It also has no effect on Na, K, Cl- and Ca ion channels.

Chemical name: S () -1- (3-dimethylaminopropyl) -1- (4-fluorophenyl) -1,3-dihydroisobenzofuran-5-nitrile oxalate Molecular weight: C20H21FN2O

This product is a white film-coated tablet, which appears white after removing the coating.

Applicable to: 1. Treatment of major depressive disorder (MDD); 2. Generalized anxiety disorder (GAD).

1 Major depression: The starting dose is 10 mg once a day, which can be increased to 20 mg once a day after one week, taken orally in the morning or evening. In general, treatment should be continued for several months or even longer. It is recommended that elderly patients or patients with liver dysfunction take 10 mg once a day?, and patients with mild or moderate renal insufficiency do not need to adjust the dose. Use with caution in patients with severe renal insufficiency. 2 Generalized anxiety: The starting dose is 10 mg once a day, which can be increased to 20 mg once a day after one week, taken orally in the morning or evening. This drug can be switched at least 14 days after discontinuing monoamine oxidase inhibitors (MAOIs). Similarly, monoamine oxidase inhibitors can be used only 14 days after discontinuing this drug. The dose should be gradually reduced when discontinuing the drug.

About 5% of patients experience insomnia, impotence, nausea, constipation, sweating, dry mouth, fatigue, and drowsiness. About 2% of patients experience headaches, upper respiratory tract infections, back pain, pharyngitis, and anxiety. Occasionally, it has been reported to cause mania or hypomania or hyponatremia. Patients with a history of convulsions should use it with caution. There are no significant changes in laboratory parameters. There are no obvious abnormalities in the electrocardiogram.

1. Patients with impaired liver and kidney function, a history of convulsions or heart disease, thyroid disease, electrolyte imbalance, other mental illness or suicidal thoughts should use it with caution; 2. Pregnant or lactating women should use it with caution; 3. Patients who are allergic to this product or Citalopram should not use it.

Precautions for children: Antidepressants are not suitable for children and adolescents under 18 years of age. In clinical trials of children and adolescents under 18 years of age, it was found that the frequency of suicidal behavior and hostility in the Lexapro group was higher than that in the placebo group. Even for clinical trials, patients' suicidal behavior should still be closely monitored. Precautions for pregnancy and lactation: Use with caution in pregnant or lactating women. Precautions for the elderly: Not yet clear.

Escitalopram oxalate is contraindicated in combination with non-selective MAOIs.

seal.

10mg

24 months

Jewim Pharmaceutical (Shandong) Co., Ltd.

• Founded in:

  1993-12-17

• Address:

  West end of Peitianmen Street, High-tech Industrial Development Zone, Tai'an City, Shandong Province

• Tax NO.:

  91370900613681048D

• Registered Funds:

  118.8505098 yuan

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