Nitroglycerin aerosol

The main pharmacological effect of all nitrates is the same, that is, relaxing vascular smooth muscle. Organic nitrates release nitric oxide (NO) in the body. NO is the same as endothelial relaxing factor, activating guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) in smooth muscle cells, thereby relaxing vascular smooth muscle, dilating peripheral arteries and veins, and having a stronger dilating effect on veins. Venous dilation causes blood to remain in the periphery, reducing the amount of blood returning to the heart, and reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arterial dilation reduces peripheral vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). Coronary artery dilation increases coronary perfusion. The overall effect is to reduce myocardial oxygen consumption, increase oxygen supply, and relieve angina pectoris. No carcinogenic and mutagenic phenomena were observed in animal experiments.

Main ingredients and chemical names: Molecular formula: C3H5N3O9 Molecular weight: 227.09

Vasodilators are drugs used primarily to treat or prevent attacks of angina pectoris.

When angina pectoris attacks, spray 1-2 times on the sublingual mucosa of the oral cavity, which is equivalent to 0.5-1 mg of nitroglycerin. When using, first remove the spray cap, put the cover on the spray head, turn the bottle upside down, aim the cover at the sublingual mucosa of the oral cavity, press the valve, and the liquid medicine will be sprayed into the oral cavity in the form of mist.

In the early stage of medication, nitrate-induced vasodilatory headache may occur, as well as facial flushing, dry mouth, dizziness, orthostatic hypotension and reflex tachycardia. Occasionally, blood pressure may drop significantly, bradycardia, angina pectoris may worsen and syncope may occur. Some patients may experience numbness in the oral mucosa.

It is contraindicated for patients with glaucoma, shock or hypotension.

1. Use of this drug may cause hypotension when drinking moderately or excessively. 2. Combination with antihypertensive drugs or vasodilators may enhance the postural hypotensive effect of nitrates. 3. Aspirin may reduce the clearance of sublingual nitroglycerin and enhance its hemodynamic effects. 4. The use of long-acting nitrates may reduce the therapeutic effect of sublingual medications. 5. Sildenafil citrate (Viagra) enhances the antihypertensive effect of organic nitrates. 6. The efficacy may be weakened when used in combination with acetylcholine, histamine and sympathomimetic amines.

Keep in a dark, airtight container in a cool place.

Each bottle contains 0.05g of nitroglycerin, each bottle contains 100 presses, and each press contains 0.5mg of nitroglycerin

Jewim Pharmaceutical (Shandong) Co., Ltd.

• Founded in:

  1993-12-17

• Address:

  West end of Peitianmen Street, High-tech Industrial Development Zone, Tai'an City, Shandong Province

• Tax NO.:

  91370900613681048D

• Registered Funds:

  118.8505098 yuan

• Website:

  Log in to view

• Email:

  Log in to view