Cefoperazone Sodium and Sulbactam Sodium for Injection

This product has good antibacterial effect on Escherichia coli, Klebsiella, Proteus, Salmonella typhi, Shigella, Citrobacter and other Enterobacteriaceae and Pseudomonas aeruginosa. Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis are highly sensitive to this product.

Main ingredients: The main ingredient of this product is: Cefoperazone sodium. Its chemical name is: (6R,7R)-3-[[(1-methyl-1H-tetrazolyl-5-yl)thio]methyl]-7-[(R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarbonylamino)-2-p-hydroxyphenyl-acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. Molecular formula: C25H26N9NaO8S2 Molecular weight: 667.66

This product is white or off-white powder.

Used for respiratory tract infections, urinary tract infections, peritonitis, cholecystitis, cholangitis and other intra-abdominal infections, sepsis, meningitis, skin and soft tissue infections, bone and joint infections, pelvic inflammatory disease, endometritis, gonorrhea and other reproductive system infections caused by sensitive bacteria.

Adults: The usual dose is 2-4g per day, which can be increased to 8g per day for severe or refractory infections. Divide the dose into equal doses and drip intravenously once every 12 hours. The maximum daily dose of sulbactam should not exceed 4g. Children: The usual dose is 40-80mg/kg per day, which can be divided into 2-4 drips. For severe or refractory infections, the dose can be increased to 160mg/kg per day, which can be divided into 2-4 drips. For newborns, the dose should be given once every 12 hours during the first week after birth. The maximum dose should not exceed 80mg/kg.

1. Skin rash is more common, reaching 2.3% or more. 2. A small number of patients may also experience diarrhea, abdominal pain, eosinophilia, and mild neutropenia. 3. Temporary increase in serum aminotransferase, alkaline phosphatase, urea nitrogen or blood creatinine. 4. Thrombocytopenia, prolonged prothrombin time, etc. can be seen in individual cases. Occasional bleeding can be prevented or controlled with vitamin K. 5. Dysbacteriosis may occur in a small number of patients. 6. Those who drink alcohol or take alcoholic drugs or beverages during the use of this product may experience a disulfiram-like reaction.

This product is contraindicated in patients who are allergic to cephalosporins or have a history of allergic shock and immediate reaction to penicillin.

Precautions for children: This product has been effectively used to treat infections in infants. However, extensive studies have not been conducted on premature infants and newborns, so this product must be used with caution after weighing the pros and cons before use in newborns and premature infants. Precautions for pregnancy and lactation: Animal experiments have not found that this product harms reproductive capacity and the fetus, but there is still a lack of sufficient controlled research data in humans. Therefore, pregnant women should use this product with caution and only use this product when it is clearly indicated. Cefoperazone and sulbactam can be secreted into breast milk in small amounts, so lactating women should use it with caution. Precautions for the elderly: The elderly have physiological liver and kidney function impairment, so this product should be used with caution and the dosage needs to be adjusted.

1. This product has a synergistic effect on certain sensitive strains of Enterobacteriaceae and Pseudomonas aeruginosa when used in combination with aminoglycoside antibiotics (gentamicin and tobramycin). 2. This product can produce hypoprothrombinemia and thrombocytopenia. When used simultaneously with the following drugs, it may cause bleeding: anticoagulant heparin, coumarin or indandione derivatives, thrombolytic drugs, non-steroidal anti-inflammatory analgesics (especially aspirin, diflunisal or other salicylic acid preparations) and sulfinpyrazone, etc. 3. This product contains a methylthiotetrazolyl side chain in its chemical structure. Therefore, drinking alcohol or intravenous injection of ethanol-containing drugs during the use of this product will inhibit the activity of acetaldehyde dehydrogenase, causing acetaldehyde accumulation in the blood, and causing disulfiram-like reactions such as drowsiness and hallucinations. Therefore, during the medication period and within 5 days after stopping the medication, patients cannot drink alcohol, take oral or intravenous injection of ethanol-containing drugs. 4. This product cannot be infused in the same bottle when used in combination with aminoglycoside antibiotics, because they may affect each other's antibacterial activity. 5 This product is contraindicated with the following drug injections: amikacin, gentamicin, kanamycin B, doxycycline, meclofenoxate, amarin (Bianmailing), diphenhydramine, potassium magnesium aspartate, hydroxyzine hydrochloride (Antalol), procainamide, aminophylline, prochlorperazine, cytochrome C, pentazocine (Zhentongxin), aprotinin, etc.

Keep tightly closed in a cool, dark and dry place.

1.5 g (C25H27N9O8S2 0.75 g and C8H11NO5S 0.75 g)

24 months.