Loratadine Tablets

Pharmacological action: This product is a long-acting tricyclic antihistamine that can relieve seasonal allergic rhinitis or non-nasal symptoms by selectively binding to peripheral H1 receptors. Toxicological studies: Genetic toxicity: No mutagenic effect of loratadine was observed in the Ames test, forward point mutation test, DNA damage test, and chromosome aberration test. In the mouse lymphoma test, positive results were observed in the inactive state and negative results in the activated state. Reproductive toxicity: Oral administration of loratadine to male rats at a dose of 64 mg/kg (approximately 50 times the clinically recommended maximum daily oral dose, calculated based on body surface area) can cause decreased fertility, as manifested by a decrease in the pregnancy rate of female rats. Oral administration of loratadine at a dose of 24 mg/kg

The main ingredient is loratadine. Chemical name: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptyl[1,2-b]pyridine-11-ene)-1-piperidinecarboxylic acid ethyl ester.

This product is white tablets.

It is used to relieve nasal or non-nasal symptoms of allergic rhinitis, such as sneezing, runny nose, itchy nose, itchy eyes and burning eyes, etc. It is also suitable for alleviating the symptoms and signs of chronic urticaria and other allergic skin diseases.

Oral administration: adults and children over 12 years old, 10 mg once a day.

In controlled clinical trials, loratadine did not demonstrate clinically significant sedation or anticholinergic effects, the incidence of which was similar to placebo, and reports of somnolence, dry mouth, weight gain, fatigue, headache, and nausea were rare.

This product is contraindicated for patients who are allergic to any ingredient or have special physical conditions.

Precautions for children: The safety of this product for children under 12 years old has not been determined. Precautions for pregnancy and lactation: Pregnant women should use with caution. Breastfeeding should be stopped during medication. Precautions for the elderly: Mild to moderate impairment of liver and kidney function has no significant effect on the metabolism and excretion of this drug, so the dosage for elderly patients is the same as that for adults.

Clinical trials have shown that when healthy adults simultaneously take loratadine (10 mg), therapeutic doses of erythromycin, carmitidine and other drugs, the blood concentration of this product and its metabolites increases slightly, and there is no significant change in its absorption, distribution and metabolism.

Keep in a sealed container and away from light. Validity period: tentatively 24 months.

10mg

30 months

Topfond Pharmaceutical Co., Ltd.

• Founded in:

  2013-11-13

• Address:

  No. 2 Guangming Road, Yicheng District, Zhumadian City

• Tax NO.:

  91411700083473072R

• Registered Funds:

  420 million yuan

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