Polycresol sulfonate solution

The pharmacological mechanism of polyphenol sulfonaldehyde is: destroy bacteria, fungi and trichomonas through high acid and protein coagulation, selectively causing necrosis or diseased tissue and columnar epithelial protein deformation. It causes vasoconstriction and plasma protein coagulation to stop bleeding. Polyphenol sulfonaldehyde has a broad spectrum of antibacterial effects, including common Gram-positive bacteria, Gram-negative bacteria, fungi and viruses, among which Gardnerella Vaginatis, anaerobic bacteria, trichomonas and Candida are particularly sensitive to it. However, Doderlein Vaginal Flore (vaginal lactobacillus flora) is basically unaffected. There is no report of drug resistance caused by this drug. Polyphenol sulfonaldehyde has a selective coagulation and exclusion effect on necrotic or diseased tissue, which can promote tissue regeneration and epithelial re-covering. Healthy squamous epithelium is not affected, but the cytoplasm and nucleus of columnar epithelium may swell after contact with this drug, and then shrink for a few seconds. Toxicology study: Acute toxicity: The LD50 of mice is 360mg/kg after intravenous administration and 2400mg/kg after oral administration; the LD50 of rats is 400mg/kg and 3500mg/kg for intravenous and oral administration respectively. The LD50 of mice is 200 times the human therapeutic dose, and the LD50 of rats is 300 times the human therapeutic dose. Chronic toxicity: Rats and dogs were given 40 times and 9 times the human therapeutic dose for 3 months, respectively, and no relevant toxic effects were found. The skin tolerance test of polycresol sulfonaldehyde was performed on the hairless back of rats. Different concentrations of polycresol sulfonaldehyde (4%, 11% and 36%) were applied in the first 10 days of the 14-day observation, which only caused transient skin redness, which lasted until the third application and then disappeared. Reproductive toxicity: Studies on pregnant rats and rabbits have shown that polycresol sulfonaldehyde has no embryotoxicity or teratogenicity. Mutagenicity/Carcinogenicity: There is no relevant study on the carcinogenicity of this product. The Ames test shows that polycresol sulfonaldehyde has no mutagenic effect. Although there are no reports on the carcinogenicity of this product, many years of clinical application have also found no mutagenic or carcinogenic effects.

Polycresol sulfonate.

This product is a reddish brown clear liquid.

1. Gynecology: used to treat cervical erosion, cervicitis, various vaginal infections (such as increased leucorrhea caused by bacteria, trichomonas and fungi), vulvar itching, and pressure ulcers caused by the use of pessaries, hemostasis after cervical polypectomy or biopsy, condyloma acuminatum and accelerate wound healing after electrocoagulation treatment; it can also be used to prevent mastitis (burning of nipple fissures). 2. Surgery and dermatology: used for local treatment of skin wounds and lesions (such as burns, limb ulcers, bedsores, chronic inflammation, etc.), can accelerate the shedding of necrotic tissue, hemostasis and promote the healing process and for the treatment of condyloma acuminatum. 3. Otolaryngology: used to treat inflammation of the oral mucosa and gums, oral ulcers and hemostasis after tonsillectomy.

Gynecology: When used for vaginal douching, the sibirin solution should be diluted with water at a ratio of 1:5. When used for local application or compress, it does not need to be diluted. Usually, the compress is applied 1-2 times a week. Before treatment, the cervix and cervical canal should be thoroughly cleaned to remove secretions. To this end, a cotton swab soaked in sibirin solution can be inserted into the cervical canal, rotated several times and removed, and then a gauze piece soaked in the solution can be gently applied to the lesion tissue for 1-3 minutes. Generally, applying for 1-2 minutes can achieve the purpose of hemostasis. Surgery and dermatology: In order to stop bleeding from the wound, a gauze piece soaked in sibirin solution can be pressed on the bleeding site for 1-2 minutes. After the bleeding stops, it is best to wipe off the residual solution. The same method can also be used to treat local burns, bedsores and limb ulcers to make the necrotic tissue easier to fall off. In these cases, the effect is better if sibirin ointment is continued to be used. For lesions of the oral mucosa and gums, the mouth must be rinsed thoroughly after treatment with sibirin solution.

In the early stages of using spirulina, local irritation symptoms may sometimes occur, but they disappear quickly on their own. When treating oral lesions, please note that its high acidity may damage tooth enamel.

During pregnancy, especially in the late stages of pregnancy, any local treatment within the cervix should be avoided. External cervical and vaginal cauterization can only be performed in extremely special circumstances. Spiraxin is no exception. At this time, the potential harm of the drug to mother and child should be fully considered. Although animal experiments have shown that this drug has no teratogenic effect, the results of human experiments have not yet been obtained, and it is not clear whether the active ingredients of this drug will be contained in the breast milk of lactating women.

Precautions for children: Keep out of reach of children. Precautions for pregnancy and lactation: See Contraindications.

Spiraline can only be applied topically. Since interactions with other drugs cannot be ruled out, avoid using more than two drugs at the same time in the same area.

This product should be stored below 25℃.

36%(g/g)

24 months

Zhejiang Shibyling Pharmaceutical Co., Ltd.

• Founded in:

  1997-05-28

• Address:

  No. 428, Yangtouhong Village, Chicheng Street, Tiantai County, Taizhou City, Zhejiang Province

• Tax NO.:

  91331023704710502F

• Registered Funds:

  10 million yuan

• Email:

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