Cholestyramine Powder

This product combines with bile acid in the small intestine to form insoluble compounds that prevent its reabsorption and are excreted with feces. After this product combines with bile acid in the small intestine, it leads to an increase in the synthesis of bile acid in the liver. Since the synthesis of bile acid uses cholesterol as a substrate, it reduces cholesterol in the liver, thereby increasing the activity of liver low-density lipoprotein receptors and removing low-density lipoprotein in plasma. This product increases the synthesis of very low-density lipoprotein in the liver, thereby increasing the concentration of triglycerides in plasma, especially in those with hypertriglyceridemia. This product reduces bile acid in serum and can relieve itching caused by excessive bile acid deposition in the skin. This product increases the incidence of small intestinal tumors in rats when taking strong carcinogens.

Cholestyramine

White or off-white powder.

This product can be used for type IIa hyperlipidemia and hypercholesterolemia. This product reduces plasma total cholesterol and low-density lipoprotein concentrations, has no effect on serum triglyceride concentrations or slightly increases them, so it is ineffective for those with simple triglyceride elevations. This product can also be used for itching caused by incomplete bile duct obstruction.

Adult oral dose: maintenance dose, 2-24 g (cholestyramine anhydrous) per day, 16 g (cholestyramine anhydrous) for antipruritic, taken in 3 times before meals or mixed with beverages. Pediatric oral dose: for lowering blood lipids, initial dose, 4 g (cholestyramine anhydrous) per day, taken in 2 times, maintenance dose is 2-24 g (cholestyramine anhydrous) per day, taken in 2 or more times.

It mostly occurs in patients who take large doses and are over 60 years old. It has been reported that long-term use of this product can occasionally cause osteoporosis. 1. The more common ones are: 1. Constipation, which is usually mild and transient, but may be severe and may cause intestinal obstruction; 2. Heartburn; 3. Indigestion; 4. Nausea and vomiting; 5. Stomach pain. 2. Less common ones are: 1. Cholelithiasis; 2. Pancreatitis; 3. Gastrointestinal bleeding or gastric ulcer; 4. Steatorrhea or malabsorption syndrome; 5. Belching; 6. Swelling; 7. Dizziness; 8. Headache.

1. Patients who are allergic to cholestyramine are contraindicated. 2. Patients with complete bile duct occlusion are contraindicated.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

Cholestyramine can delay or reduce the absorption of other drugs taken with it, especially acidic drugs, and reduce enterohepatic circulation. These drugs include: thiazide diuretics, propranolol, digoxin and other alkaloids, loperamide, phenylbutazone, barbiturates, estrogen, progesterone, thyroid hormone, warfarin and some antibiotics. To avoid drug interactions, other drugs can be taken 1 hour before or 4-6 hours after taking this product.

Keep away from light, sealed and stored in a dry place.

5g:4g (cholestyramine dry product)

24 months

Nanjing Lifecare Pharmaceutical Co., Ltd.

• Founded in:

  2003-07-08

• Address:

  Room 502, East Building, No. 293, Zhongshan East Road, Xuanwu District

• Tax NO.:

  9132010275126607X2

• Registered Funds:

  45.24517 million yuan

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