Pralidoxime chloride injection

This product is a hydroxyl compound. Its quaternary ammonium group can tend to the cationic site of the phosphorylated cholinesterase that has lost its vitality and combined with the organophosphorus insecticide. Its nucleophilic group can directly combine with the phosphorylated group of cholinesterase and then detach from cholinesterase together, so that cholinesterase can be restored to its original state and regain its vitality. The revival effect of aging cholinesterase that has been inhibited by organophosphorus insecticides for more than 36 hours is very poor. It has no revival effect on cholinesterase inhibited by chronic organophosphorus insecticide poisoning. This product has a significant effect on nicotine-like symptoms caused by organophosphorus insecticides, but a weak effect on phytosteryl-like symptoms, and no significant effect on central nervous system symptoms. The hydroxyl content of this product is 79.5%, while that of pralidoxime iodide is only 51.9%; therefore, the efficacy of 1g of this product is equivalent to 1.5g of pralidoxime iodide. This product is water-soluble (640mg/ml, 25℃), has good stability, is completely absorbed locally, and can be used for intramuscular injection. 43 cases of organophosphorus pesticide poisoning were reported, and the average activity of blood cholinesterase was about 50% of the normal value. After intramuscular injection of 0.5-1g of this product, clinical poisoning symptoms mostly disappeared within 30 minutes to 1 hour, and blood cholinesterase activity recovered to more than 70% of the normal value.

Pralidoxime chloride

It has different degrees of resurrection effect on the activity of cholinesterase inhibited by acute organophosphate insecticides, and is used to rescue poisoning by various organophosphate insecticides. However, it has poor effect on poisoning by malathion, trichlorfon, dichlorvos, dimethoate, dimefox, mipafox and schradan, etc.; it has no resurrection effect on cholinesterase inhibited by carbamate insecticides.

For general poisoning, 0.5-1g is injected intramuscularly or slowly intravenously; for severe poisoning, 1-1.5g is used. Later, it can be repeated 1-3 times every 1.5-2 hours according to the clinical condition and blood cholinesterase level. For intravenous drip method and medication days, please refer to iodine pralidoxime. 1. The common dosage for adults is 0.5-1g is injected intramuscularly or slowly intravenously, and the injection can be repeated as needed. 2. The common dosage for children is 20mg/kg based on body weight, and the usage is the same as that for adults.

After injection, it may cause nausea, vomiting, increased heart rate, temporary S-T segment depression and prolonged Q-T time on the electrocardiogram. Injection too quickly may cause dizziness, blurred vision, diplopia, and uncoordinated movements. Excessive doses may inhibit cholinesterase, inhibit breathing, and cause epileptic seizures.

Not yet clear.

1. This product is a cholinesterase reactivator, which can indirectly reduce the accumulation of acetylcholine and has a significant effect on the neuromuscular junction of skeletal muscle. Atropine has a direct antagonistic effect on the accumulation of acetylcholine and a stronger effect on the autonomic nerves. The combined use of the two drugs has a significant clinical effect. This product has an enhanced biological effect of atropine, so the dose of atropine should be reduced when the two drugs are used at the same time. The first dose of atropine for general poisoning is 2-4 mg, once every 10 minutes, and 4-6 mg for severe poisoning, every 5-10 minutes, intramuscular or intravenous injection, until atropinization occurs. Atropinization should be maintained for 48 hours, and then the dose of atropine should be gradually reduced or the injection time should be extended. 2. This product is easily decomposed in alkaline solution and is forbidden to be used in combination with alkaline drugs.

Keep away from light and store in a sealed container.

2ml:0.25g

Tonghua Huikang Biopharmaceutical Co., Ltd.

• Founded in:

  2011-06-23

• Address:

  No. 10, Yongkang Road, Chaoyang Town, Huinan County

• Tax NO.:

  91220523574085680R

• Registered Funds:

  80 million yuan

• Email:

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