Josamycin Tablets

This product is a macrolide antibiotic produced by Streptomyces narbonensis var. Josamyceticus. Its antibacterial spectrum is similar to that of erythromycin. Its antibacterial effect on Staphylococcus and Streptococcus is slightly worse than that of erythromycin, but it still has antibacterial activity against induced resistant strains. Meningococci and Bordetella pertussis are sensitive to this product. It has good antibacterial effect on anaerobic bacteria such as Peptococcus, Peptostreptococcus, Propionibacterium and Eubacterium. Intracellular pathogens such as Mycoplasma, Chlamydia and Legionella are also sensitive to this product. This product does not induce Staphylococcus to macrolide resistance and is a non-inducible antibiotic.

The main ingredient of this product is josamycin. Molecular formula: C42H69NO15, molecular weight: 828.

This product is a sugar-coated tablet, which appears white or off-white after removing the sugar coating.

This product is suitable for pharyngitis and tonsillitis caused by Streptococcus pyogenes, sinusitis, otitis media, acute bronchitis and oral abscess caused by sensitive bacteria, pneumonia caused by Mycoplasma pneumoniae, skin and soft tissue infections caused by sensitive bacteria, and can also be used for infections with Staphylococci resistant to penicillin and erythromycin.

Adults: 0.8-1.2g per day, and for severe infections, the dosage can be increased to 1.6g per day; for children: 30mg/kg per day based on body weight, divided into 3-4 times and taken on an empty stomach (1 hour before or 3-4 hours after a meal).

1 Gastrointestinal reactions include diarrhea, nausea, vomiting, upper and middle abdominal pain, pain in the mouth and tongue, decreased appetite, etc. The incidence is related to the dosage. The incidence of gastrointestinal reactions of this product is significantly lower than that of erythromycin. 2 Hepatotoxic symptoms such as fatigue, nausea, vomiting, abdominal pain, fever and abnormal liver function are rare, and jaundice is occasionally seen. 3 Taking this product in large doses, especially in patients with liver and kidney diseases or elderly patients, may cause hearing loss, which can mostly be recovered after stopping the drug. 4 Allergic reactions are occasionally seen, manifested as drug fever, rash, eosinophilia, etc. 5 Others, occasionally arrhythmias, oral or vaginal candidiasis.

Patients who are allergic to this product, erythromycin or other macrolide antibiotics are contraindicated.

Precautions for children: This experiment has not been conducted and there are no reliable references. Precautions for pregnancy and lactation: 1. Since this product can pass through the blood-placental barrier, although it cannot be detected in the blood of newborns and fetuses, pregnant women should still weigh the pros and cons when taking this product. 2. Because this product can enter breast milk, lactating women should stop breastfeeding when taking it during breastfeeding. Precautions for the elderly: Elderly patients taking large doses of this product may cause hearing loss, but most of them can recover after stopping the drug.

1. This product does not affect the action of liver drug metabolizing enzymes, and has no incompatibility with theophylline, oral contraceptives and cyclosporine. 2. This product may interfere with the bactericidal activity of penicillins when used in combination. 3. This product has no obvious effect on the metabolism of drugs such as aminophylline.

Sealed, store in a dry place.

0.2 g

24 months

Hangzhou Minsheng Pharmaceutical Co., Ltd.

• Founded in:

  1963-11-29

• Address:

  No. 36, Linping Avenue, Donghu Street, Linping District, Hangzhou City, Zhejiang Province

• Tax NO.:

  913301101430685558

• Registered Funds:

  88.97 million yuan

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