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Josamycin

Josamycin structure

CAS No:
16846-24-5
Formula:
C42H69NO15
Chemical Name:
Josamycin
Synonyms:
Leucomycin V,3-acetate 4B-(3-methylbutanoate);Leucomycin A3;Oxacyclohexadecane,leucomycin V deriv.;Antibiotic YL 704A3;Turimycin A5;Kitasamycin A3;Josamycin;Wilprafen;Josacine;Vilprafen;Jomybel;Iosalide;EN 141;Josamina;11033-18-4;35414-05-2;39416-64-3;56689-45-3;801993-04-4
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

White or slightly yellowish powder, slightly hygroscopic.ChEBI: A macrolide antibiotic produced by certain strains of Streptomyces narbonensis var. josamyceticus.

Josamycin Basic Attributes

Molecular Weight：

827.99

Exact Mass：

827.99

EC Number：

240-871-6

DSSTox ID：

DTXSID8023183

Characteristics

PSA：

206.05000

XLogP3：

3.88

Appearance：

white to slightly yellow

Density：

1.1547 (rough estimate)

Melting Point：

131.5 °C

Boiling Point：

763.27°C (rough estimate)

Flash Point：

484.7±34.3 °C

Refractive Index：

1.6220 (estimate)

Water Solubility：

Soluble in ethanol

Storage Conditions：

2-8°C

Toxicity：

LD50 oral in rat: > 7gm/kg

Specific rotation：

D25 -70° (c = 1 in ethanol)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

OH4725810

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory.

Josamycin Use and Manufacturing

A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection.

Computed Properties

Molecular Weight:828.0
XLogP3:2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:14
Exact Mass:827.46672049
Monoisotopic Mass:827.46672049
Topological Polar Surface Area:206
Heavy Atom Count:58
Complexity:1390
Undefined Atom Stereocenter Count:16
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a macrolide antibiotic produced by Streptomyces (Streptomycesnarbonensisvar.Josamyceticus). Its antibacterial spectrum is similar to that of erythromycin. Its antibacterial effect on Staphylococcus and Streptococcus is slightly worse than that of erythromycin, but it still has antibacterial activity against induced resistant strains. Meningococci and Bordetella pertussis are sensitive to this product. It has good antibacterial effect on anaerobic bacteria such as Peptococcus, Peptostreptococcus, Propionibacterium and Eubacterium. Intracellular pathogens such as Mycoplasma, Chlamydia and Legionella are also sensitive to this product. This product does not induce Staphylococcus to macrolide resistance and is a non-inducible antibiotic.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Josamycin Tablets
Ingredients	Josamycin.
Indication	1. This product does not affect the action of liver drug metabolizing enzymes, and has no incompatibility with theophylline, oral contraceptives and cyclosporine. 2. This product may interfere with the bactericidal activity of penicillins when used in combination. 3. This product has no obvious effect on the metabolism of drugs such as aminophylline.
Specifications	50mg (50,000 units)

Josamycin

Josamycin Tablets
Ingredients	Josamycin.
Indication	1. This product does not affect the action of liver drug metabolizing enzymes, and has no incompatibility with theophylline, oral contraceptives and cyclosporine. 2. This product may interfere with the bactericidal activity of penicillins when used in combination. 3. This product has no obvious effect on the metabolism of drugs such as aminophylline.
Specifications	200mg (200,000 units)
Manufacturer	Beijing Wanhui Double-Crane Pharmaceutical Company Limited

See More Related Drugs

Registered Holders

Beijing HengChuangJingCheng Medical Technology Co., Ltd.

China
Active
MICROBIOPHARM JAPAN CO., LTD.

European Union
Active
Beijing Yidu Zhengkang Health Technology Co., Ltd.

China
Inactive

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