Adefovir Dipivoxil Tablets

The main ingredient of this product is adefovir dipivoxil. Chemical name: 9-[2-[[di(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine. Molecular weight: C20H32N5O8P

This product is off-white tablets.

Patients must use this product under the guidance of a physician with experience in treating chronic hepatitis B. 1. The recommended dose for adults (18-65 years old) is 10 mg once a day, orally before or after meals. 2. The optimal course of treatment has not yet been determined. Do not exceed the recommended dose. 3. Patients should regularly monitor hepatitis B biochemical indicators, virological indicators and serum markers, at least once every 6 months.

Weakness, headache, abdominal pain, nausea, flatulence, diarrhoea, and indigestion.

Adefovir dipivoxil is contraindicated in patients with confirmed hypersensitivity to any component of this product.

Precautions for children: The efficacy and safety of adefovir dipivoxil in patients under 18 years of age have not been determined. This product should not be used in children and adolescents. Precautions for pregnancy and lactation: The effects of pregnant women and adefovir dipivoxil on mother-to-child transmission of HBV have not been studied. Therefore, infants should be immunized to prevent them from being infected with hepatitis B virus. It is not known whether adefovir is secreted into human breast milk. Lactating women should avoid breastfeeding when using this product. Precautions for the elderly: The efficacy and safety of adefovir dipivoxil in elderly patients over 65 years of age have not been determined.

1. Adefovir dipivoxil is rapidly converted to adefovir in the body. At concentrations significantly higher than those observed in vivo (>4000 times), adefovir has no inhibitory effect on any of the following common human CYP450 enzymes: CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Adefovir is not a substrate for these enzymes. However, it is not clear whether adefovir induces CYP450 enzymes. 2. Based on the results of in vitro experiments and the renal elimination pathway of adefovir, the possibility of adefovir acting as an inhibitor or substrate and interacting with other drugs mediated by CYP450 is very small. Adefovir is excreted through the kidneys by glomerular filtration and active tubular secretion. 10 mg of adefovir dipivoxil and other renal elimination pathways

Store in a cool, sealed container.

10mg*20s

24 months

Hunan Fangsheng Pharmaceutical Co., Ltd.

• Founded in:

  1997-10-13

• Address:

  No. 789, Lusong Road, Changsha High-tech Zone

• Tax NO.:

  91430000183855019M

• Registered Funds:

  440.45112 million yuan

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