Perphenazine tablets

This product is a piperazine derivative of the phenothiazine class, and its pharmacological effects are similar to those of chlorpromazine. Its antipsychotic effect is mainly related to its blocking of dopamine receptors (DA2) in the mesolimbic system and mesocortical pathways related to emotional thinking, while blocking the alpha-adrenaline receptors in the reticular formation ascending activation system is related to its sedative and tranquilizing effects. This product has a strong antiemetic effect and a weak sedative effect.

The main ingredient of this product is perphenazine, and its chemical name is: 4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol.

This product is a sugar-coated tablet, which appears white after removing the sugar coating.

1. It has a good effect on hallucinations, delusions, thinking disorders, apathy, stupor, anxiety and agitation. It is used for schizophrenia or other psychotic disorders. Because of its weak sedative effect, it has little effect on blood pressure. It is suitable for organic mental illness, senile mental disorders and children's aggressive behavior disorders. 2. It can stop vomiting, vomiting or stubborn hiccups caused by various reasons.

Oral: For the treatment of schizophrenia, start with a low dose, 2-4 mg at a time, 2-3 times a day. Then increase by 6 mg every 1-2 days, gradually increasing to the commonly used therapeutic dose of 20-60 mg a day. The maintenance dose is 10-20 mg a day. For vomiting, 2-4 mg at a time, 2-3 times a day.

1. Mainly extrapyramidal reactions, such as: tremor, rigidity, drooling, bradykinesia, akathisia, acute dystonia, etc. Long-term and large-scale medication can cause tardive dyskinesia. 2. It can cause an increase in plasma prolactin concentration, and possible related symptoms are: galactorrhea, gynecomastia, menstrual disorders, amenorrhea. Dry mouth, blurred vision, fatigue, dizziness, tachycardia, constipation, sweating, etc. may occur. 3. Rare adverse reactions include postural hypotension, neutropenia and toxic liver damage. Allergic rash and malignant syndrome are occasionally seen.

Patients with basal ganglia lesions, Parkinson's disease, Parkinson's syndrome, bone marrow suppression, glaucoma, coma, and allergy to phenothiazines.

Precautions for children: The dosage for children under 12 years old has not been determined. Precautions for pregnancy and lactation: Pregnant women should use with caution. Lactating women should stop breastfeeding while using this product. Precautions for the elderly: Reduce the dosage according to the situation, start with a small dose and increase slowly.

This product is a piperazine derivative of the phenothiazine class. Its pharmacological effects are similar to those of chlorpromazine. Its antipsychotic effect is mainly related to its blocking of dopamine receptors (DA2) in the mesolimbic system and mesocortical pathways related to emotional thinking, while its blocking of the ?-adrenaline receptors in the reticular formation ascending activation system is related to its sedative and tranquilizing effects. This product has a strong antiemetic effect and a weak sedative effect. [Pharmacokinetics] After oral administration, it is distributed throughout the body, excreted through bile, and partially reabsorbed in the intestines. The half-life (t1/2) is 9 hours. This product can enter the fetus through umbilical blood and can be excreted from breast milk. This product has a high lipophilicity and protein binding rate. The metabolism and excretion of this product are significantly reduced in children and the elderly.

Keep away from light and store in sealed container.

2mg

30 months

Jiangsu Huanghe Medical Co., Ltd.

• Founded in:

  1999-12-21

• Address:

  Huayuan Village, Development Zone, Funing County, Yancheng City

• Tax NO.:

  91320900717455133J

• Registered Funds:

  55.07 million yuan

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